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Thermo Scientific™ Pierce™ Cysteine-Reactive Tandem Mass Tag Reagents

Perform measurement of protein and peptide cysteine modifications (S-nitrosylation, oxidation and disulfide bridges) by multiplex quantitative mass spectrometry.

Manufacturer:  Thermo Scientific™ 90103

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Catalog No. PI90103


 

Specifications

Description

Perform measurement of protein and peptide cysteine modifications (S-nitrosylation, oxidation and disulfide bridges) by multiplex quantitative mass spectrometry with Thermo Scientific™ Pierce Cysteine-Reactive Tandem Mass Tag Reagents.


Additional Information and Online Ordering »

Tandem Mass Tag™ (TMT™) Reagents enable concurrent identification and multiplexed quantitation of proteins in different samples using tandem mass spectrometry. The iodoTMT™ Reagents are sets of isobaric (mass and structure) isomers that are iodoacetyl-activated for covalent, irreversible labeling of sulfhydryl (-SH) groups. Similar to iodoacetamide, iodoTMT Reagents react specifically with reduced cysteines (Cys) in peptides and proteins. IodoTMT Reagents can be differentiated by mass spectrometry (MS), enabling quantitation of the relative abundance of cysteine modifications, such as S–nitrosylation, oxidation and disulfide bonds, in cultured cells grown or treated with different conditions.

Highlights:

  • Specific – only reacts with sulfhydryl groups (reduced, unmodified cysteine residues)

  • Irreversible – labeled proteins and peptides are not susceptible to reducing agents

  • Flexible – options for duplex isotopic (MS) or sixplex isobaric (MS/MS) quantitation

  • Versatile – can be used to study cysteine modifications (e.g. di-sulfide bridges, S-nitrosylation)

Note:

IodoTMT Products replace our previously offered CysTMT Reagents, which utilized a dithiopyridine reactive group to reversibly label cysteine sulfhydryls.

Description & Specifications

Specifications

iodoTMTsixplex Isobaric Mass Tag Labeling Kit
Multi-component kit with -126 to -131 iodoTMT6 label reagents
5 complete sixplex (5 x 6-way) experiments
Albumin (bovine), 2.5mg
30 rxn kit
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Promotions

  • To make a purchase through the 2016 Thermo Scientific™ Mass Spec Rewards Program, select a combination of products from this list within and contact your local sales representative for a quote. Please mention the appropriate Promo Code from the table within.

    12/31/17