accessibility menu, dialog, popup

UserName

Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
Product Type 
  • (109)
  • (1)
  • (1)
  • (1)
Chemical Reactivity 
  • (32)
  • (1)
  • (12)
  • (8)
  • (2)
  • (41)
  • (5)
  • (1)
Cleavable 
  • (3)
  • (2)
  • (1)
  • (20)
  • (83)
Crosslinker Type 
  • (72)
  • (33)
  • (4)
Format 
  • (1)
  • (65)
  • (1)
  • (19)
  • (23)

Filtered Search Results

Products from some of our suppliers do not display in filtered search results. Please clear all filters to see these products.

Narrow Results

Narrow Results

category

brands

  • (1)
  • (3)
  • (109)

Product Type

  • (109)
  • (1)
  • (1)
  • (1)

Chemical Reactivity

  • (32)
  • (1)
  • (12)
  • (8)
  • (2)
  • (41)
  • (5)
Show all

Cleavable

  • (3)
  • (2)
  • (1)
  • (20)
  • (83)

Crosslinker Type

  • (72)
  • (33)
  • (4)

Format

  • (1)
  • (65)
  • (1)
  • (19)
  • (23)

Spacer

  • (7)
  • (53)
  • (49)
Keyword Search:
1 – 15 of 86 results
1

Thermo Scientific Pierce™ Pierce™ SM(PEG)2, No-Weigh™ Format

Thermo Scientific™ Pierce™ SM(PEG)2 is hetero-bifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.

2

Thermo Scientific Pierce™ Pierce™ SM(PEG)12, No-Weigh™ Format

Thermo Scientific™ Pierce™ SM(PEG)12 is hetero-bifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.

3

Thermo Scientific™ SPB (succinimidyl-[4-(psoralen-8-yloxy)]-butyrate)

Crosslink amines to DNA with this crosslinker composed of NHS-ester and psoralen reactive groups; conjugates to DNA via light-activated intercalation next to pyrimidine bases.

4

Thermo Scientific™ BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

Content And Storage Upon receipt store desiccated at -20°C.
Description BS(PEG)5
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 532.5
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety NHS Ester
Spacer Arm Length 21.7 Å
PEGylated Yes
5

Thermo Scientific™ BS3 (bis(sulfosuccinimidyl)suberate)

Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Cleavable No
Product Type Crosslinker
Molecular Weight (g/mol) 572.43
Solubility Water
PEGylated No
6

Thermo Scientific™ SM(PEG)8 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

7

Thermo Scientific™ Mass Spectrometry Cleavable Crosslinkers  DFS Item

Improve sensitivity of mass spectrometry detection of crosslinked proteins with MS-cleavable DSSO and DSBU heterotrifunctional crosslinkers.

Content And Storage Upon receipt store at 4°C protected from moisture.
Cleavable By CID using MS
Water Soluble No
Form Powder
Solubility DMF, DMSO
Quantity 10 x 1 mg
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety NHS Ester
PEGylated No
8

Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.

9

Thermo Scientific™ SM(PEG)4 (PEGylated SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Form Solid
Molecular Weight (g/mol) 513.5
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 24.6 Å
Product Line Pierce
PEGylated Yes
10

MilliporeSigma™ Calbiochem™ SATA

Reacts with primary amines to add protected sulfhydryl groups.

11

Thermo Scientific™ SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate))

Crosslink amines to sulfhydryls with this long crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 12-atom (14.2A) spacer arm.

12

Thermo Scientific™ L-Photo-Leucine

Diazirine analogs of leucine and methionine to express proteins in cell culture that will crosslink their protein interactors upon UV-light activation in vivo.

13

Thermo Scientific™ L-Photo-Methionine

Diazirine analogs of leucine and methionine to express proteins in cell culture that will crosslink their protein interactors upon UV-light activation in vivo.

14

Thermo Scientific™ BM(PEG)2 (1,8-bismaleimido-diethyleneglycol)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, pegylated, water-soluble crosslinker composed of maleimide groups and 2-unit (14.7A) PEG spacer arm.

15

Thermo Scientific™ Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Description Sulfo-SMCC
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 436.37
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Maleimide, Sulfo-NHS Ester
Spacer Arm Length 8.3 Å
PEGylated No