Protein Modification Reagents

Chemical agents used to modify the amino acid side chains of proteins in order to alter their native charges, block or expose reactive binding sites, inactivate functional groups, and change functional groups to create targets for crosslinking and labeling.

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MilliporeSigma™ Calbiochem™ DM-NITROPHEN™ Reagent, Tetrasodium Salt

Caged Ca2+ chelator that undergoes a major and rapid decrease in Ca2+-binding affinity upon photolysis

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Thermo Scientific™ Immobilized Trypsin, TPCK Treated (Agarose Resin)

Cleave the carboxyl-side of Arg and Lys residues with trypsin that isTPCK-treated to block chymotrypsin activity; its immobilized form allows enzyme removal after digestion.

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Thermo Scientific™ Guanidine-HCl

Pure, crystalline guanidium hydrochloride (GdnHCl, GuHCl), CAS 50-01-1; denaturant for protein biology methods (elution, solubilization, refolding, storage).

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MilliporeSigma™ Calbiochem™ Cleland’s Reagent

Protective agent for SH groups

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Specifications

Content And Storage	2°C to 8°C
CAS	12-3-3483
Product Type	Calbiochem Cleland’s Reagent
Form	Powder
Molecular Weight (g/mol)	154.24
Solubility	EtOH, Water
Purity	≥97% by titration
Synonym	DTT, Dithiothreitol
Molecular Formula	C4H10O2S2

Thermo Scientific™ Pierce™ SATP (N-succinimidyl-S-acetylthiopropionate)

Short (4.1A), amine-reactive (NHS ester) sulfhydryl-addition reagent; creates stable (protected yet exposable) -SH group for protein crosslinking strategies.

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Thermo Scientific™ Pierce™ Mercaptoethylamine-HCl

Pure, crystalline 2-aminoethanethiol (2-MEA-HCl, also called cysteamine-HCl), CAS 156-57-0; selectively reduces antibody hinge-region disulfide bonds.

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Thermo Scientific™ TMS(PEG)12 Branched Methyl-PEG-NHS-Ester Reagent

A three-branched, polyethylene glycol compound (3 times 12 PEG units) activated as an NHS ester for covalent PEGylation of primary amines on proteins or assay surfaces.

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Thermo Scientific™ MM(PEG)24 Methyl-PEG-Maleimide Reagent

Pegylate sulfhydryls (-SH groups) on proteins (cysteine residues) or assay surfaces using MS(PEG); sulfhydryl-reactive (maleimide), PEG compounds (12 and 24 EG units).

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Thermo Scientific™ Pierce™ 2-Mercaptoethanol

Pure, liquid (equals 14M), beta-mercaptoethanol (bME, 2BME, 2-ME, b-mer), CAS 60-24-2; thiol reducing agent for cleaving protein disulfide bonds (cystines cysteines).