SQSTM1 Monoclonal Antibody (GT381), Invitrogen™

Description

Keep as concentrated solution. Positive Control: HepG2, A549, H1299, Huh-7 (untreated), Huh-7 (3 μM Thapsigargin treatment for 12 hr), Huh-7 (3 μM Thapsigargin treatment for 24 hr). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.