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Invitrogen™ Predictor™ hERG Fluorescence Polarization Assay Kit

Predictor™ hERG Fluorescence Polarization Assay Kit

Supplier: Invitrogen™ PV5365

Catalog No. PV5365

$2,195.00 / Each

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Description

The Predictor™ hERG Fluorescence Polarization Assay Kit provides a set of validated components to perform hERG channel biochemical binding studies in the absence of radioligand. The assay was designed to identify potential hERG channel blockers by producing data that accurately correlates with patch-clamp electrophysiology studies. The assay is based on the principle of fluorescence polarization where a red-shifted fluorescent tracer is displaced from the hERG channel by compounds that bind to the channel. Assay performance was validated with a panel of established hERG channel blockers. Results from the Predictor™ assay demonstrate a high correlation with those obtained from patch clamp techniques.

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Specifications

Color	Red
Detection Method	Fluorescence
Quantity	1 Kit
Content And Storage	PV5365 Predictor™ hERG Fluorescence Polarization Assay Kit (Other materials are required separately; please refer to the protocol) Includes: • Predictor™ hERG Membranes • Predictor™ hERG Tracer Red • Predictor™ hERG Buffers • E-4031 • Predictor™ hERG Fluorescence Polarization Assay Protocol • Certificate of Analysis Store the Predictor™ hERG Membranes at -80°C. The Predictor™ Tracer Red, Predictor™buffers, and E-4301 should be stored at -20°C.
Druggable Target	Ion Channels
Readout	End Point
System Type	Predictor™ System
Product Line	Predictor™
Product Type	Assay Kit

Conjugate	Predictor hERG Tracer Red
For Use With (Equipment)	Microplate Reader
Packaging	384-well Plate
Assay Entry	Biochemical binding
Gene Symbol	hERG
Shipping Condition	Dry Ice
Target Entry	hERG
Protein Family	Ion Channels

Product Suggestions Documents

Documents

Product Information

Manuals

Instrument setup guide- Synergy4- Predictor Version: version 1.1 File size: 1,002.1 kB

Instrument setup guide- Safire2- Predictor Version: version 1.1 File size: 972.5 kB

Instrument setup guide- Paradigm- Predictor Version: 10.2.2012 File size: 1 MB

Manual: Predictor hERG Fluorescence Polarization Assay (Japanese) Version: 28October2009 File size: 1.1 MB

Instrument setup guide- InfiniteM1000- Predictor Version: version 1.1 File size: 692.7 kB

Instrument setup guide- InfiniteF500- Predictor Version: version 1.1 File size: 693 kB

Instrument setup guide- EnVision- Predictor Version: 4.13.12 File size: 1.6 MB

Instrument setup guide- PHERAstar- Predictor Version: version 1.1 File size: 1.4 MB

Instrument setup guide- Synergy2- Predictor Version: version 1.1 File size: 999.3 kB

Predictor hERG Fluorescence Polarization Assay FAQ General File size: 73.4 kB

Scientific Resources

Brochures

SelectScreen hERG Screening Service Compound Supply Information - Europe File size: 144.2 kB

SelectScreen hERG Screening Service Compound Supply Information - North America File size: 144.2 kB

SelectScreen hERG Screening Service Compound Supply Information - Asia Pacific File size: 144.5 kB

Posters

Performance of Predictor FP Assay: A tool for high-throughput screening of hERG channel affinity File size: 92.9 kB

Performance of the Predictor Fluorescence Polarization Assay File size: 427.5 kB

For Research Use Only. Not for use in diagnostic procedures.