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PLZF Mouse anti-Human, Mouse, Alexa Fluor 488, Clone: Mags.21F7, eBioscience™
Mouse Monoclonal Antibody
$170.28 - $421.08
Specifications
| Antigen | PLZF |
|---|---|
| Clone | Mags.21F7 |
| Host Species | Murine |
| Gene Alias | Zbtb16, Zinc finger and BTB domain-containing protein 16 |
| Species Reactivity | Human, Mouse |
Disclaimers:
For Research Use Only.
Description
This Mags.21F7 monoclonal antibody reacts with human and mouse promyelocytic leukemia zinc finger (PLZF), a member of the BTB-POZ family of transcription factors. Expression of this transcriptional repressor in immune cells differs between mice and humans. In mice, PLZF is highly expressed in immature CD1d-resricted NKT2 and NKT1 cells, and a subset of gamma delta (Vg1.1+Vd6.3+) T cells. Studies have also demonstrated expression of PLZF in non-invariant CD1d-restricted T cells, as well as non-CD1d-restricted innate T cells. In humans, PLZF is expressed in NK cells, gamma delta T cells, as well as CD4 and CD8+ T cells. PLZF is also expressed in MR1-specific mucosal-associated invariant T cells, as well as in MHC Class II-restricted T cells that develop via a thymocyte-thymocyte interaction in humans. PLZF exists as a homodimer or in complex with PLZP, and has been shown to be involved in the development of NKT cells, NK cell function, cellular quiescence, and growth suppression. Finally, PLZF has been shown to inhibit gene expression induced by retinoic acid receptor.Specifications
| PLZF | |
| Murine | |
| Human, Mouse | |
| RUO | |
| Conjugated | |
| Primary | |
| aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer |
| Mags.21F7 | |
| Zbtb16, Zinc finger and BTB domain-containing protein 16 | |
| Flow Cytometry (Intracellular Staining) | |
| Alexa Fluor 488 | |
| Store at 2-8°C. Do not freeze. Light-sensitive material. | |
| Monoclonal | |
| 0.5mg/mL |