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Phospho-ATM (Ser1981) Monoclonal Antibody (10H11.E12), eFluor™ 660, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Supplier: Thermo Fisher Scientific 50904642
Description
Description: This 10H11.E12 monoclonal antibody recognizes the human, mouse, and rat ataxia-telangiectasia (ATM) protein when phosphorylated on serine 1981. ATM belongs to the family of PI3 kinases and functions by coordinating cell cycle arrest and initiation of DNA repair through the phosphorylation of a multitude of substrates in response to DNA damage and oxidative stress. ATM exists as dimers or multimers in its inactive state but in response to DNA breaks, becomes activated through formation of monomers and autophosphorylation. Activated ATM is recruited to the site of DNA double strand breaks where it halts the cell cycle and initiates DNA repair through the phosphorylation of downstream DNA damage response pathway members. Loss of functional activity of ATM results in ataxia-telangiectasia (AT), a disease characterized by early onset neurodegeneration and predisposition to cancer. AT patients are immunodeficient, radiosensitive, and have an increased risk of certain cancer types such as lymphoma and leukemia. Applications Reported: This 10H11.E12 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This 10H11.E12 antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test.
Phospho-ATM (Ser1981) Monoclonal antibody specifically detects Phospho-ATM (Ser1981) in Human, Mouse, Rat samples. It is validated for Flow Cytometry.Specifications
Phospho-ATM (Ser1981) | |
Monoclonal | |
5 μL/Test | |
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
Q13315, Q62388 | |
ATM | |
Affinity chromatography | |
RUO | |
11920, 300711, 472 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
10H11.E12 | |
eFluor 660 | |
ATM | |
AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1 | |
Mouse | |
100 Tests | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 κ |
For Research Use Only.