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IL-23 Mouse anti-Mouse, Clone: 5B2, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $549.55

Specifications

Antigen IL-23
Clone 5B2
Host Species Mouse
Gene Alias Interleukin-23, p40, p19
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013667

 
affymetrix
14723381
50μg Each for $201.55

5013668

 
affymetrix
14723385
500μg Each for $549.55
Description & Specifications

Specifications

Antigen IL-23
Clone 5B2
Host Species Mouse
Gene Alias Interleukin-23, p40, p19
Species Reactivity Mouse
Applications Enzyme Linked Immunosorbent Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The 5B2 antibody reacts with the p19 subunit of mouse IL-23. The 5B2 antibody in combination with the C17.8 antibody yields an improved IL-23 sandwich ELISA with greater sensitivity than was achievable with previous assays. The 5B2 antibody is a non-neutralizing antibody.

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN gamma. Mouse IL-23 does induce strong proliferation of memory T cells (but not naïve T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN gamma production by naïve and memory T cells, as compared to IL-12.