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Genlantis™ PrimaPure™ Human Dermal Microvascular Endothelial Cells (HMVEC) and Kits


Functionally characterized

Manufacturer: genlantis  PH10005A

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Catalog No. PH10005A

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Description & Specifications

Specifications

Cell Type Human Dermal Microvascular Endothelial Cells (Adult)
Quantity >500000 Cells
Source Human Neonatal Foreskin or Adult Skin
For Use With (Application) For the study of angiogenesis, tumor metastasis, wound healing, inflammation, macromolecule transport, drug metabolism
Media Type HMVEC Growth Medium
Sufficient For 16 Population Doublings

HMVEC are isolated from normal human neonatal foreskin or adult skin capillaries. They are cryopreserved at second passage and can be cultured and propagated at least 16 population doublings. They are responsive to cytokine stimulation in the expression of cell adhesion molecules. HMVEC express CD36 constitutively, while large vessel endothelial cells do not. HMVEC is an organ-specific endothelial cell system for the study of angiogenesis1, tumor metastasis2,3, wound healing4, inflammation5,6, macromolecule transport7, and drug metabolism8. There is growing evidence of differences in physiology and pharmacology between microvascular endothelial cells and macrovascular endothelial cells9,10.

  • Single donors to allow variability comparisons
  • Each lot tested negative for HIV, Hepatitis B and C, mycoplasma, bacteria, yeast, and fungi
  • Performance guaranteed with Genlantis media and reagents

1. Swerlick, R.A. et.al, J. Invest. Dermatol. 97(2):190 (1991).
2. Folkman, J. et al, Nature 288:551 (1980).
3. Lee, K.H. et al, J. Invest. Dermatol. 98(1):79 (1992).
4. Deryugina, E.I. et al, Hybridoma 15(4):279 (1996).
5. Sepp, N.T. et al, J. Invest. Dermatol. 104(2):277 (1995).
6. Swerlick, R.A. et al, J. Invest. Dermatol. 100(1):111S (1993).
7. Hanasaki, K. et al, J. Bio. Chem. 270(13):7533 (1995).
8. Pruckler, J.M. et al, Pathobiology 61:283 (1993).
9. Foster, C.A. et al, J. Dermatol. 21(11):847 (1994).
10. Schnitzer, J.E. et al, BBRC. 199(1):11 (1994).