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ACTN4 (M01), Mouse anti-Human, Mouse, Rat, Clone: 4D10, Abnova™
Mouse monoclonal antibody raised against a partial recombinant ACTN4.
Supplier: Abnova Corporation H00000081M01
Description
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
Sequence: KEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKSpecifications
ACTN4 | |
Monoclonal | |
Unconjugated | |
PBS with no preservative; pH 7.4 | |
NM_004924 | |
ACTN4 | |
ACTN4 (NP_004915, 592 a.a. ∼ 701 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG2a κ |
ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot | |
4D10 | |
Mouse monoclonal antibody raised against a partial recombinant ACTN4. | |
ACTN4 | |
ACTININ-4/DKFZp686K23158/FSGS/FSGS1 | |
Mouse | |
Affinity chromatography | |
RUO | |
81 | |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
Liquid |