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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1 – 15 of 86 results
1

Thermo Scientific™ Pierce™ EDC, No-Weigh™ Format

Immobilize or conjugate proteins using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (CAS 25952-53-8), a water-soluble, carboxyl-to-amine crosslinker.

Shipping Condition Wet Ice
Content And Storage Upon receipt store desiccated at -20°C.
Description EDC
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 191.7
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Carboxyl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Carbodiimide
Spacer Arm Length 0.0 Å
PEGylated No
2

MilliporeSigma™ Calbiochem™ SATA

Reacts with primary amines to add protected sulfhydryl groups.

5

Thermo Scientific™ Mass Spectrometry Compatible Crosslinkers

Improve mass spectrometry detection of crosslinked proteins and interactions with DSPP and TBDSPP heterotrifunctional crosslinkers.

Content And Storage Upon receipt store at -20°C protected from moisture.
Format Standard
Cleavable No
Product Type Crosslinker
Form Solid
Reactive Moiety NHS Ester
Spacer Arm Length 4.3 Å
Quantity 50 mg
Labeling Method Chemical Labeling
Crosslinker Type Homotrifunctional
Chemical Reactivity Amine-Amine
Product Line MS Reagents
PEGylated No
6

Thermo Scientific™ DMS (dimethyl suberimidate)

Crosslink amines to amines with dimethyl suberimidate (CAS 34490-86-3); composed of imidoester groups at either end of a membrane-permeable, 8-atom spacer arm.

7

Thermo Scientific™ DST (disuccinimidyl tartrate)

Crosslink amines to amines with disuccinimidyl tartrate, composed of NHS-ester groups and a diol-containing spacer arm (6.4A) that is periodate-cleavable.

8

Thermo Scientific™ DTBP (Wang and Richard's Reagent)

Crosslink amines to amines with dithiobispropionimidate; composed of imidoester groups at either end of a reducible (cleavable) disulfide-containing spacer arm.

9

Thermo Scientific™ EGS (ethylene glycol bis(succinimidyl succinate))

Crosslink amines to amines with this membrane permeable crosslinker composed of NHS-ester groups and a 16.1A hydroxylamine-cleavable spacer arm.

10

Thermo Scientific™ DMP (dimethyl pimelimidate)

Crosslink amines to amines with dimethyl pimelimidate (CAS 58537-94-3); composed of imidoester groups and a membrane-permeable, 7-atom spacer arm.

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Description DMP
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 259.17
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Imidoester
Spacer Arm Length 9.2 Å
Product Line Pierce
PEGylated No
11

Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.

12

Thermo Scientific™ EMCH (N-ε-maleimidocaproic acid hydrazide)

Crosslink sulfhydryls to periodate-treated glycoprotein sugars with this mid-length (11.8A) crosslinker containing maleimide and hydrazide groups.

13

Thermo Scientific™ SM(PEG)8 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

14

Thermo Scientific™ SMPT (4-succinimidyloxycarbonyl-alpha-methyl-α(2-pyridyldithio)toluene)

Crosslink amines to sulfhydryls with this crosslinker containing NHS-ester and pyridyldithiol groups at the ends of an aromatic, 6-atom (11.2A) spacer arm.

15

Thermo Scientific™ Sulfo-EGS (ethylene glycol bis(sulfosuccinimidyl succinate))

Crosslink amines to amines with a crosslinker composed of sulfo-NHS-ester groups and hydroxylamine-cleavable spacer arm; water-soluble for cell-surface protein crosslinking.