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Thermo Scientific™ SMPT (4-succinimidyloxycarbonyl-alpha-methyl-α(2-pyridyldithio)toluene)

Numéro de catalogue. PI21558
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Quantity:
50 mg
Numéro de catalogue. Quantity
PI21558 50 mg
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Numéro de catalogue. PI21558

Supplier: Thermo Scientific™ LSG21558

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Description

Crosslink amines to sulfhydryls with this crosslinker containing NHS-ester and pyridyldithiol groups at the ends of an aromatic, 6-atom (11.2A) spacer arm.

Thermo Scientific™ Pierce SMPT is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form strong (hindered) yet cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

  • Contains a hindered disulfide bond; forms stable immunotoxins
  • In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-iminothiolane
  • Reactive groups: NHS ester and pyridyldisulfide
  • Reactive toward: amino and sulfhydryl groups

Spécifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable By Thiols
Description SMPT
Molecular Weight (g/mol) 388.46
PEGylated No
Spacer Arm Length 11.2 Å
Content And Storage Upon receipt store desiccated at 4°C.
Cell Permeability Yes
Shipping Condition Ambient
Product Line Pierce
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety NHS Ester, Pyridyldisulfide
Spacer Medium (10 to 30 Å)
Form Powder
Quantity 50 mg
Solubility DMF, DMSO
Format Standard
Water Soluble No
Product Type Crosslinker
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For Research Use Only. Not for use in diagnostic procedures.