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Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Catalog No. PI21857
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50 mg
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Catalog No. Quantity
PI21857 50 mg
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Catalog No. PI21857 Supplier Thermo Scientific™ Supplier No. 21857
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Description

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.

Thermo Scientific™ Pierce SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

  • Widely used in immunochemistry; conjugates used in drug carrier systems, antibody production and enzyme immunoassays
  • Can be used as a protein thiolation reagent
  • Reactive groups: NHS ester and pyridyldisulfide
  • Reactive toward: amino and sulfhydryl groups

Specifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable By Thiols
Description SPDP
Molecular Weight (g/mol) 312.36
PEGylated No
Spacer Arm Length 6.8 Å
Content And Storage Upon receipt store at -20°C protected from moisture.
Cell Permeability Yes
Shipping Condition Ambient
Product Line Pierce
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety NHS Ester, Pyridyldisulfide
Spacer Short (<10 Å)
Form Powder
Quantity 50 mg
Solubility DMF, DMSO
Format Standard, Premium-grade
Water Soluble No
Product Type Crosslinker
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For Research Use Only. Not for use in diagnostic procedures.