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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1

Thermo Scientific™ GMBS (N-γ-maleimidobutyryl-oxysuccinimide ester)

Crosslink amines to sulfhydryls with this short crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 6-atom (7.3A) spacer arm.

2

Thermo Scientific™ Sulfo-GMBS (N-γ-maleimidobutyryl-oxysulfosuccinimide ester)

Crosslink amines to sulfhydryls with this short, water-soluble crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of an aliphatic, 6-atom (7.3A) spacer arm.

3

Thermo Scientific™ BMH (bismaleimidohexane)

Crosslink sulfhydryls to sulfhydryls (cysteine residues in proteins or peptides) with this long crosslinker composed of maleimide groups and 11-atom (13.0A) spacer arm.

4

Thermo Scientific™ DTME (dithiobismaleimidoethane)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, cleavable crosslinker composed of maleimide groups and 11-atom (13.3A) disulfide spacer arm.

5

Thermo Scientific™ L-Photo-Methionine

Diazirine analogs of leucine and methionine to express proteins in cell culture that will crosslink their protein interactors upon UV-light activation in vivo.

6

Thermo Scientific™ Pierce™ Premium Grade Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate)

Optimize applications where product integrity and risk minimization are paramount our highest quality formulation of this popular amine-to-sulfhydryl crosslinker.

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 436.37
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Maleimide, Sulfo-NHS Ester
Spacer Arm Length 8.3 Å
Product Line Pierce
PEGylated No
7

Thermo Scientific™ Pierce™ Premium Grade DSP (dithiobis(succinimidyl propionate))

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this popular amine-reactive, cleavable crosslinker.

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 404.42
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Formulation Dithiobis(succinimidylpropionate); powder solid
Reactive Moiety NHS Ester
Spacer Arm Length 12.0 Å
Product Line Pierce
PEGylated No
8

Thermo Scientific™ BM(PEG)3 (1,11-bismaleimido-triethyleneglycol)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, pegylated, water-soluble crosslinker composed of maleimide groups and 3-unit (17.8A) PEG spacer arm.

9

Thermo Scientific™ AMAS (N-α-maleimidoacet-oxysuccinimide ester)

Crosslink amines to sulfhydryls with this very short crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 4-atom (4.4A) spacer arm.

10

Thermo Scientific™ PDPH (3-(2-pyridyldithio)propionyl hydrazide)

Crosslink sulfhydryls to periodate-treated glycoprotein sugars via cleavable disulfide bonds using this short crosslinker containing pyridyldithiol and hydrazide groups.

11

Thermo Scientific™ SM(PEG)8 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

12

Thermo Scientific™ SDAD (NHS-SS-Diazirine) (succinimidyl 2-((4,4'-azipentanamido)ethyl)-1,3'-dithiopropionate)

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

13

Thermo Scientific™ Sulfo-SDA (Sulfo-NHS-Diazirine) (sulfosuccinimidyl 4,4'-azipentanoate)

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

14

Thermo Scientific™ TMEA (tris(2-maleimidoethyl)amine)

A 3-way, sulfhydryl-to-sulfhydryl crosslinker; tris (2-maleimidoethyl) amine; composed of three maleimide groups on short spacer arms; conjugate protein or peptide cysteines.

15

Thermo Scientific™ Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of a water-soluble, 8-atom (9.4A) spacer arm.