Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Autophagy Inhibitor, 3-MA
Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker. Acts as an inhibitor of III PI3-Kinase.
MilliporeSigma™ Calbiochem™ Erastin
A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.
MilliporeSigma™ Calbiochem™ Wnt Antagonist I, IWR-1-endo
Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC50 = 131 nM) & TNKS2/PARP5b (IC50≥ 56 nM). Suppress Wnt-stimulated transcription activity (IC50 = 180 nM).
Thermo Scientific Chemicals Oxymetazoline hydrochloride
CAS: 2315-02-8 Molecular Formula: C16H25ClN2O
MilliporeSigma™ Calbiochem™ PKCζ Pseudosubstrate Inhibitor, Myristoylated
PKCζ Pseudosubstrate Inhibitor is a myristoylated, cell-permeable, reversible, substrate competitive inhibitor of protein kinase Cζ.
MilliporeSigma™ Calbiochem™ InSolution™ γ-Secretase Inhibitor X
InSolution™ γ-Secretase Inhibitor X is a 1 mM solution in DMSO. A highly potent inhibitor of g-secretase (IC50 = 17, 48, 67 nM for Aβtotal, Aβ40 & Aβ42 in SHSY5Y cells overexpressing spβA4CTF).
MilliporeSigma™ Calbiochem™ Cdk1 Inhibitor IV, RO-3306
RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively).
MilliporeSigma™ Calbiochem™ Genistein, Soybean
A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 μM).
MilliporeSigma™ Calbiochem™ EPAC Inhibitor, ESI-09
A cell-permeable compound that targets cAMP-binding domain of EPAC/cAMP-GEF and inhibits cAMP-dependent EPAC GEF activity (IC50 = 1.4 and 3.2 μM, respectively, against EPAC2 and EPAC1).
MilliporeSigma™ Calbiochem™ Emetine, Dihydrochloride
Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.
MilliporeSigma™ Calbiochem™ Cdc42/Rac1 GTPase Inhibitor, ML141
The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ CaCC Blocker IV, Benzbromarone
A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat
MilliporeSigma™ Calbiochem™ Alsterpaullone
A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC50 = 4 nM) and Cdk1/cyclin B (IC50 = 35 nM).
MilliporeSigma™ Calbiochem™ Metformin
An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.
MilliporeSigma™ Calbiochem™ Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac
The Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac controls the biological activity of Sialyltransferase.