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Protein Modification Reagents

Chemical agents used to modify the amino acid side chains of proteins in order to alter their native charges, block or expose reactive binding sites, inactivate functional groups, and change functional groups to create targets for crosslinking and labeling.
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1 – 15 of 121 results
1

Thermo Scientific™ Pierce™ 2-Mercaptoethanol

Pure, liquid (equals 14M), beta-mercaptoethanol (bME, 2BME, 2-ME, b-mer), CAS 60-24-2; thiol reducing agent for cleaving protein disulfide bonds (cystines cysteines).

2

MilliporeSigma™ Endoproteinase Lys-C, Sequencing Grade, Lysobacter enzymogenes

Designed for protein sequencing or sequence verification, analysis of protein structural domains, and cleavage of fusion proteins

3

MilliporeSigma™ Endopeptidase Lys-C, Achromobacter lyticus

Specifically hydrolyzes amide and peptide ester bonds at carboxylic side of lysine and S-aminoethylcysteine residues

4

MilliporeSigma™ Calbiochem™ BAPTA/AM

Can be loaded into wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA

Membrane Permeable Y
Content And Storage -20°C
CAS 126150-97-8
Product Type Calbiochem BAPTA/AM
Form Solid
Solubility DMSO
Purity ≥90% by TLC
Synonym 1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
7

MilliporeSigma™ Calbiochem™ Carboxypeptidase B, Porcine Pancreas

Native carboxypeptidase B catalyzes the release of C-terminal from basic amino acids, arginine, lysine, or ornithine from polypeptides

9

Thermo Scientific™ Immobilized Pepsin (Agarose Resin)

Generate and purify Fab and F(ab')2 fragments from antibodies with acidic endopeptidase (pepsin) immobilized onto beaded agarose resin.

10

Thermo Scientific™ Pierce™ Sodium meta-Periodate

Gently oxidize glycoprotein carbohydrate sugars to create reactive aldehydes (carbonyls) for crosslinking and immobilization using NaIO4 (CAS 7790-28-5).

11

Thermo Scientific™ Pierce™ Hydroxylamine-HCl

NH2OH (CAS 7803-49-8) to cleave Asn-Gly peptide bonds or deprotect sulfhydryls following S-acetylthioacetate modification with SATA reagent.

12

Thermo Scientific™ MA(PEG)12 Methyl-PEG-Amine Compound

MA(PEG)n: methyl- and amine-capped polyethylene glycol compounds containing 4 to 24 PEG units; use for surface-modification and molecule-pegylation applications.

Content And Storage Upon receipt store product at -20°C protected from moisture. Product is shipped at ambient temperature.
Product Type Amine Compound
Form Solid
Spacer 12 ethylene glycol units
Solubility Water
Reactive Moiety Amine, Primary Amine
Label Type Polyethylene Glycol (PEG), Blocking Groups
Chemical Reactivity Aldehyde
13

Thermo Scientific™ CA(PEG)8 Carboxy-PEG-Amine Compound

CA(PEG)n: pegylated amino acids of the form carboxy-PEG-amine; with 4 to 24 polyethylene glycol units; for surface- and molecule-pegylation applications.

Content And Storage Store desiccated at 4°C. Shipped at ambient temperature.
Product Type Amine Compound
Spacer 8 ethylene glycol units
Solubility Water
Reactive Moiety Amine, Carboxylic Acid, Primary Amine
Label Type Conjugating Groups, Polyethylene Glycol (PEG)
14

MilliporeSigma™ Calbiochem™ Cleland’s Reagent, Molecular Biology Grade

Protective agent for SH groups

Content And Storage 2°C to 8°C
CAS 12-3-3483
Product Type Calbiochem Cleland’s Reagent
Form Crystalline Solid
Molecular Weight (g/mol) 154.24
Solubility EtOH, Water
Purity ≥99% by titration
Synonym 1,4-Dithiothreitol, DTT
Molecular Formula C4H10O2S2
15

MilliporeSigma™ Calbiochem™ Caffeic Acid

Reported to have anti-carcinogenic anti-inflammatory properties.