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Thermo Scientific™ Pierce™ Iodoacetic Acid

Get rapid carboxymethylation of reduced cysteine residues with Thermo Scientific™ Pierce™ Iodoacetic Acid and Iodoacetamide.

Manufacturer:  Thermo Scientific™ PI35603

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Catalog No. PI35603


 

Specifications

Description

Get rapid carboxymethylation of reduced cysteine residues with Thermo Scientific™ Pierce™ Iodoacetic Acid and Iodoacetamide.

Iodoacetic Acid (IAA) can react with several protein functional groups but is typically used for specific S-carboxymethylation of sulfhydryls (reduced cysteines).

Iodoacetic acid reacts with sulfhydryls on cysteines, imidazolyl side chain nitrogens of histidines, the thioether of methionine and the primary amine group of lysines.The rate of reaction and specificity is dependent on the ionization level, which can be manipulated by the pH of the reaction condition.

Highlights:
  • React at slightly alkaline pH for specific S-carboxymethylation of free sulfhydryls
  • React at low pH for specific carboxymethylation of methionines
  • React at high pH to favor carboxymethylation of histidines and lysines
  • Methylate reduced cysteine peptide fragments in protease digests for mass spectrometry
Description & Specifications

Specifications

27mL of 100mM solution
Iodoacetic acid
Carboxymethane
185.95
Iodoacetic Acid
Sulfhydryl
500mg
No
Promotions

Promotions

  • To make a purchase through the 2016 Thermo Scientific™ Mass Spec Rewards Program, select a combination of products from this list within and contact your local sales representative for a quote. Please mention the appropriate Promo Code from the table within.

    12/31/17