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Thermo Scientific Chemicals Midostaurin
Supplier: Thermo Scientific Chemicals J62917MCR
Description
Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Specifications
| 1 mg | |
| -30°C to -10°C | |
| 120685-11-2 | |
| 570.64 | |
| 235°C to 260°C | |
| Powder | |
| CO[C@]1(C)[C@@H]([C@H]2O[C@]1(C)N1C3=C(C=CC=C3)C3=C1C1=C(C4=CC=CC=C4N21)C1=C3CNC1=O)N(C)C(=O)C1=CC=CC=C1 | |
| 570.65 |
| White to off-white | |
| Inhibits a variety of serine/threonine and tyrosine kinases including PKC | |
| C35H30N4O4 | |
| PKC412; 4'-N-Benzoylstaurosporine | |
| Midostaurin | |
| IIQIEMHSDLLZQA-QZPVEUDVSA-N | |
| N-[(15R,16S,17R,18S)-17-methoxy-17,18-dimethyl-5-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1¹âµ,¹â¸.0²,â¶.0â·,²â·.0â¸,¹³.0¹â¹,²â¶.0²â°,²âµ]octacosa-1(26),2(6),7(27),8,10,12,20(25),21,23-nonaen-16-yl]-N-methylbenzamide |
Chemical Identifiers
| 120685-11-2 | |
| C35H30N4O4 | |
| PKC412; 4'-N-Benzoylstaurosporine |
Safety and Handling
Recommended Storage : Store at -20°C
RUO – Research Use Only