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Protein Modification Reagents

Chemical agents used to modify the amino acid side chains of proteins in order to alter their native charges, block or expose reactive binding sites, inactivate functional groups, and change functional groups to create targets for crosslinking and labeling.
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1 – 15 of 121 results
1

Thermo Scientific™ Pierce™ Hydroxylamine-HCl

NH2OH (CAS 7803-49-8) to cleave Asn-Gly peptide bonds or deprotect sulfhydryls following S-acetylthioacetate modification with SATA reagent.

2

Thermo Scientific™ MA(PEG)12 Methyl-PEG-Amine Compound

MA(PEG)n: methyl- and amine-capped polyethylene glycol compounds containing 4 to 24 PEG units; use for surface-modification and molecule-pegylation applications.

Content And Storage Upon receipt store product at -20°C protected from moisture. Product is shipped at ambient temperature.
Product Type Amine Compound
Form Solid
Spacer 12 ethylene glycol units
Solubility Water
Reactive Moiety Amine, Primary Amine
Label Type Polyethylene Glycol (PEG), Blocking Groups
Chemical Reactivity Aldehyde
3

MilliporeSigma™ Calbiochem™ Cleland’s Reagent, Molecular Biology Grade

Protective agent for SH groups

Content And Storage 2°C to 8°C
CAS 12-3-3483
Product Type Calbiochem Cleland’s Reagent
Form Crystalline Solid
Molecular Weight (g/mol) 154.24
Solubility EtOH, Water
Purity ≥99% by titration
Synonym 1,4-Dithiothreitol, DTT
Molecular Formula C4H10O2S2
4

MilliporeSigma™ Calbiochem™ Caffeic Acid

Reported to have anti-carcinogenic anti-inflammatory properties.

5

Thermo Scientific™ MA(PEG)24 Methyl-PEG-Amine Compound

MA(PEG)n: methyl- and amine-capped polyethylene glycol compounds containing 4 to 24 PEG units; use for surface-modification and molecule-pegylation applications.

9

Thermo Scientific™ MS(PEG)12 Methyl-PEG-NHS-Ester Reagent

Pegylate amines (-NH2 groups) on proteins (lysine residues) or assay surfaces using MS(PEG)n, amine-reactive (NHS ester), methyl-capped PEG compounds (4 to 24 EG units).

Content And Storage Store desiccated at -20°C.
Product Type NHS-Ester Reagent
Spacer 12 ethylene glycol units
Solubility Water
Reactive Moiety Active Ester, Succinimidyl Ester, NHS Ester
Label Type Polyethylene Glycol (PEG), Blocking Groups
Chemical Reactivity Amine
10

MilliporeSigma™ Calbiochem™ DM-NITROPHEN™ Reagent, Tetrasodium Salt

Caged Ca2+ chelator that undergoes a major and rapid decrease in Ca2+-binding affinity upon photolysis

11

MilliporeSigma™ Calbiochem™ Cleland’s Reagent

Protective agent for SH groups

Content And Storage 2°C to 8°C
CAS 12-3-3483
Product Type Calbiochem Cleland’s Reagent
Form Powder
Molecular Weight (g/mol) 154.24
Solubility EtOH, Water
Purity ≥97% by titration
Synonym DTT, Dithiothreitol
Molecular Formula C4H10O2S2
12

Thermo Scientific™ Trypsin, TPCK Treated

Thermo Scientific Pierce TPCK Trypsin is a serine endoprotease that is applicable to amino acid analysis and protein sequencing, mapping and structural studies; the immobilized form allows sample separation after treatment.

13

Thermo Scientific™ Pierce™ 2-Mercaptoethanol

Pure, liquid (equals 14M), beta-mercaptoethanol (bME, 2BME, 2-ME, b-mer), CAS 60-24-2; thiol reducing agent for cleaving protein disulfide bonds (cystines cysteines).

14

Thermo Scientific™ TMS(PEG)12 Branched Methyl-PEG-NHS-Ester Reagent

A three-branched, polyethylene glycol compound (3 times 12 PEG units) activated as an NHS ester for covalent PEGylation of primary amines on proteins or assay surfaces.

15

Thermo Scientific™ Pierce™ SATP (N-succinimidyl-S-acetylthiopropionate)

Short (4.1A), amine-reactive (NHS ester) sulfhydryl-addition reagent; creates stable (protected yet exposable) -SH group for protein crosslinking strategies.