Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ D,L-Sulforaphane
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
MilliporeSigma™ Calbiochem™ GSK-3 Inhibitor XVI
GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively).
MilliporeSigma™ Calbiochem™ Berberine Chloride
A highly potent and selective oxysterol EBI2 (GPR183) agonist (K
MilliporeSigma™ Calbiochem™ (-)-Blebbistatin
The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
MilliporeSigma™ Calbiochem™ (±)-Blebbistatin
(±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis in vertebrate cells.
MilliporeSigma™ Calbiochem™ CA-074 Me
CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
MilliporeSigma™ Calbiochem™ APT1 Inhibitor, palmostatin B
The APT1 Inhibitor, palmostatin B controls the biological activity of APT1.
MilliporeSigma™ Calbiochem™ Granzyme B Substrate VIII, Colorimetric
A colorimetric substrate for granzyme B (kcat/Km = 6.6 x 104 M-1s-1).
MilliporeSigma™ Calbiochem™ Glucose Transporter Inhibitor IV, WZB117
The Glucose Transporter Inhibitor IV, WZB117 controls the biological activity of Glucose Transporter.
MilliporeSigma™ Calbiochem™ HIF-Hydroxylase Inhibitor, DMOG
The HIF-Hydroxylase Inhibitor, DMOG, also referenced under CAS 89464-63-1, controls the biological activity of HIF-Hydroxylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Cdc42/Rac1 GTPase Inhibitor, ML141
The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ CaCC Blocker IV, Benzbromarone
A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat
MilliporeSigma™ Calbiochem™ RIP1 Inhibitor II, 7-Cl-O-Nec-1
RIP1 Inhibitor II, 7-Cl-O-Nec-1, CAS 852391-15-2, is a cell-permeable, highly selective RIP1 inhibitor. Blocks RIP1-dependent necroptosis (EC50 = 206nM in Jurkat cells).
MilliporeSigma™ Calbiochem™ Bortezomib
Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity.