Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ TLR3/dsRNA Complex Inhibitor
The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.
MilliporeSigma™ Calbiochem™ Granzyme B Inhibitor I
The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ InSolution™ Q-VD-OPh, Non-O-methylated
InSolution™ Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively).
MilliporeSigma™ Calbiochem™ CXCR4 Antagonist I, AMD3100
The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ γ-Secretase Inhibitor XX
This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ≈72% in Tg2576 mutant APP transgenic mouse model.
MilliporeSigma™ Calbiochem™ Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free
Aprotinin, Bovine, Recombinant, Nicotiana sp, Animal-Free - CAS 9087-70-1, is a heat and acid-stable competitive, reversible inhibitor of serine proteases.
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MilliporeSigma™ Calbiochem™ Ubiquitin Aldehyde
Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover.
MilliporeSigma™ Calbiochem™ Etoposide
Etoposide, CAS 33419-42-0, is cell-permeable inhibitor of topoisomerase II inhibitor (IC50 = 59.2μM). Displays anti-tumor activity.
MilliporeSigma™ Calbiochem™ Autophagy Inhibitor, 3-MA
Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker. Acts as an inhibitor of III PI3-Kinase.
MilliporeSigma™ Calbiochem™ Erastin
A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.
MilliporeSigma™ Calbiochem™ Wnt Antagonist I, IWR-1-endo
Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC50 = 131 nM) & TNKS2/PARP5b (IC50≥ 56 nM). Suppress Wnt-stimulated transcription activity (IC50 = 180 nM).
Thermo Scientific Chemicals Oxymetazoline hydrochloride
CAS: 2315-02-8 Molecular Formula: C16H25ClN2O
MilliporeSigma™ Calbiochem™ PKCζ Pseudosubstrate Inhibitor, Myristoylated
PKCζ Pseudosubstrate Inhibitor is a myristoylated, cell-permeable, reversible, substrate competitive inhibitor of protein kinase Cζ.
MilliporeSigma™ Calbiochem™ InSolution™ γ-Secretase Inhibitor X
InSolution™ γ-Secretase Inhibitor X is a 1 mM solution in DMSO. A highly potent inhibitor of g-secretase (IC50 = 17, 48, 67 nM for Aβtotal, Aβ40 & Aβ42 in SHSY5Y cells overexpressing spβA4CTF).