
Crosslinking Reagents
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Thermo Scientificâ„¢ Pierceâ„¢ EDC, No-Weighâ„¢ Format
Immobilize or conjugate proteins using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (CAS 25952-53-8), a water-soluble, carboxyl-to-amine crosslinker.
Shipping Condition | Wet Ice |
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Content And Storage | Upon receipt store desiccated at -20°C. |
Description | EDC |
Cleavable | No |
Water Soluble | Yes |
Form | Powder |
Molecular Weight (g/mol) | 191.7 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Carboxyl |
Cell Permeability | No |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Short (<10 AÌŠ) |
Reactive Moiety | Carbodiimide |
Spacer Arm Length | 0.0 AÌŠ |
PEGylated | No |
MilliporeSigmaâ„¢ Calbiochemâ„¢ THIOLYTEâ„¢ Monobromobimane Reagent, Fluorescent Labeling Compound
Used to label E.coli thioredoxin.
Thermo Scientificâ„¢ Mass Spectrometry Compatible Crosslinkers
Improve mass spectrometry detection of crosslinked proteins and interactions with DSPP and TBDSPP heterotrifunctional crosslinkers.
Content And Storage | Upon receipt store at -20°C protected from moisture. |
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Format | Standard |
Cleavable | No |
Product Type | Crosslinker |
Form | Solid |
Reactive Moiety | NHS Ester |
Spacer Arm Length | 4.3 AÌŠ |
Quantity | 50 mg |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homotrifunctional |
Chemical Reactivity | Amine-Amine |
Product Line | MS Reagents |
PEGylated | No |
Thermo Scientificâ„¢ TMEA (tris(2-maleimidoethyl)amine)
A 3-way, sulfhydryl-to-sulfhydryl crosslinker; tris (2-maleimidoethyl) amine; composed of three maleimide groups on short spacer arms; conjugate protein or peptide cysteines.
Thermo Scientificâ„¢ NHS-Phosphine
Derivatize proteins or amine surfaces for selective conjugation, detection or purification of azide-tagged targets with these activated phosphine compounds.
Thermo Scientificâ„¢ Mass Spectrometry Cleavable Crosslinkers
Improve sensitivity of mass spectrometry detection of crosslinked proteins with MS-cleavable DSSO and DSBU heterotrifunctional crosslinkers.
Content And Storage | Upon receipt store at 4°C protected from moisture. |
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Cleavable | By CID using MS |
Water Soluble | No |
Form | Powder |
Solubility | DMF, DMSO |
Quantity | 10 x 1 mg |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homobifunctional |
Chemical Reactivity | Amine-Amine |
Cell Permeability | Yes |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 AÌŠ) |
Reactive Moiety | NHS Ester |
PEGylated | No |
Shipping Condition | Ambient |
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Content And Storage | Upon receipt store at -20°C protected from light and moisture. |
Cleavable | By Thiols |
Water Soluble | Yes |
Form | Powder |
Molecular Weight (g/mol) | 492.4 |
Solubility | Water |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Chemical Reactivity | Amine-Nonselective |
Cell Permeability | No |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 AÌŠ) |
Spacer Arm Length | 18.2 AÌŠ |
PEGylated | No |
Thermo Scientificâ„¢ DSS (disuccinimidyl suberate), No-Weighâ„¢ Format
Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.
Cleavable | No |
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PEGylated | No |
Cleavable | No |
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Water Soluble | No |
Form | Powder |
Molecular Weight (g/mol) | 326.26 |
Solubility | DMF, DMSO |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homobifunctional |
Chemical Reactivity | Amine-Amine |
Cell Permeability | Yes |
Format | Standard, Single-use |
Product Type | Crosslinker |
Spacer | Short (<10 AÌŠ) |
Reactive Moiety | NHS Ester |
Spacer Arm Length | 7.7 AÌŠ |
PEGylated | No |
Thermo Scientific Pierceâ„¢ Pierceâ„¢ SM(PEG)2, No-Weighâ„¢ Format
Thermo Scientificâ„¢ Pierceâ„¢ SM(PEG)2 is hetero-bifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.
Thermo Scientificâ„¢ Sulfo-NHS (N-hydroxysulfosuccinimide), No-Weighâ„¢ Format
Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.
Molecular Weight (g/mol) | 217.13 |
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Solubility | Water |
PEGylated | No |
Thermo Scientificâ„¢ Pierceâ„¢ DSP, No-Weighâ„¢ Format
Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.
Content And Storage | Upon receipt store desiccated at 4°C. |
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Description | DSP |
Cleavable | By Thiols |
Water Soluble | No |
Form | Powder |
Molecular Weight (g/mol) | 404.42 |
Solubility | DMF, DMSO |
Labeling Method | Chemical Labeling |
Crosslinker Type | Homobifunctional |
Chemical Reactivity | Amine-Amine |
Cell Permeability | Yes |
Format | Standard, Single-use, Premium-grade |
Product Type | Crosslinker |
Spacer | Medium (10 to 30 AÌŠ) |
Reactive Moiety | NHS Ester |
Spacer Arm Length | 12.0 AÌŠ |
PEGylated | No |
Thermo Scientific Pierceâ„¢ Pierceâ„¢ SM(PEG)12, No-Weighâ„¢ Format
Thermo Scientificâ„¢ Pierceâ„¢ SM(PEG)12 is hetero-bifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.