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Thermo Scientific™ Pierce™ BS2G-d0 and BS2G-d4 Crosslinker Mass Pair

Crosslink amines to amines using these heavy (deuterated) and light matched pairs of a 7.7A, NHS-ester crosslinker for mass spectrometry analysis of protein interactions.

Manufacturer: thermo scientific™  PI21610*

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Catalog No. PI21610


Description & Specifications


Description Pierce BS2G-d0
Formulation Bis(sulfosuccinimidyl) glutarate-d0; powder solid
Quantity 10mg
Sufficient For 19mL of typical 1X (1mM) reaction solution, or approx. 5 uses at 2mg reagent per use

Thermo Scientific™ Pierce BS2G-d0/d4 reagents form a matched set of heavy (deuterated) and light mass varieties of a short, amine-reactive crosslinker that facilitates the identification of crosslinked peptides by mass spectrometry.


  • Well-characterized, high-purity, deuterium-labeled crosslinker and its hydrogen-containing analog
  • Instructions edited by an expert in the crosslinking/MS strategy field
  • Suberate- and glutarate-based reagent pair - provides a “molecular ruler” option to study inter- and intra-molecular distances to gain structural information not possible with just one reagent
  • Efficient and convenient - requires only microgram amounts of protein; an excellent alternative to NMR or X-ray crystallography-based methods that require large amounts of protein, special solvents or crystal formation
  • Reactive groups: Sulfo-NHS ester (homobifunctional)
  • Reactive toward: amino groups