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Thermo Scientific™ Sulfo-LC-SPDP (sulfosuccinimidyl 6-(3'-(2-pyridyldithio)propionamido)hexanoate)

Catalog No. PI21650
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Quantity:
50 mg
Catalog No. Quantity
PI21650 50 mg
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Catalog No. PI21650

Supplier: Thermo Scientific™ 21650

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Description

Crosslink amines to sulfhydryls with this water-soluble sulfo-NHS-ester and pyridyldithiol groups on 10-atom spacer arms to form cleavable disulfide bonds with cysteines.

Thermo Scientific™ Pierce Sulfo-LC-SPDP is a water-soluble, long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteines.

Highlights:

  • Forms cleavable disulfide bonds with sulfhydryls
  • Releases a detectable byproduct after reacting with free sulfhydryl groups; by measuring the release of pyridine-2-thione at 343nm, the reaction progression can be monitored
  • Reactive groups: sulfo-NHS ester and pyridyldisulfide
  • Reactive toward: amino and sulfhydryl groups

Specifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable By Thiols
Description Sulfo-LC-SPDP
Molecular Weight (g/mol) 527.57
PEGylated No
Spacer Arm Length 15.7 Å
Content And Storage Upon receipt store at -20°C protected from moisture.
Cell Permeability No
Shipping Condition Ambient
Product Line Pierce
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Pyridyldisulfide, Sulfo-NHS Ester
Spacer Medium (10 to 30 Å)
Form Powder
Quantity 50 mg
Solubility Water
Format Standard
Water Soluble Yes
Product Type Crosslinker
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For Research Use Only. Not for use in diagnostic procedures.