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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1

Thermo Scientific™ BM(PEG)2 (1,8-bismaleimido-diethyleneglycol)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, pegylated, water-soluble crosslinker composed of maleimide groups and 2-unit (14.7A) PEG spacer arm.

2

Thermo Scientific™ L-Photo-Methionine

Diazirine analogs of leucine and methionine to express proteins in cell culture that will crosslink their protein interactors upon UV-light activation in vivo.

3

Thermo Scientific™ BM(PEG)3 (1,11-bismaleimido-triethyleneglycol)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, pegylated, water-soluble crosslinker composed of maleimide groups and 3-unit (17.8A) PEG spacer arm.

4

Thermo Scientific™ BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

Content And Storage Upon receipt store desiccated at -20°C.
Description BS(PEG)5
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 532.5
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety NHS Ester
Spacer Arm Length 21.7 Å
PEGylated Yes
5

Thermo Scientific™ EMCS (N-ε-malemidocaproyl-oxysuccinimide ester)

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 8-atom (9.4A) spacer arm.

6

Thermo Scientific™ AMAS (N-α-maleimidoacet-oxysuccinimide ester)

Crosslink amines to sulfhydryls with this very short crosslinker composed of NHS-ester and maleimide groups at ends of an aliphatic, 4-atom (4.4A) spacer arm.

7

Thermo Scientific™ BS3-d4 (bis(sulfosuccinimidyl) 2,2,7,7-suberate-d4)

Crosslink amines to amines using these heavy (deuterated) and light matched pairs of an 11.4A, NHS-ester crosslinker for mass spectrometry analysis of protein interactions.

8

Thermo Scientific™ SM(PEG)24 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

9

Thermo Scientific™ EMCH (N-ε-maleimidocaproic acid hydrazide)

Crosslink sulfhydryls to periodate-treated glycoprotein sugars with this mid-length (11.8A) crosslinker containing maleimide and hydrazide groups.

10

Thermo Scientific™ Sulfo-SIAB (sulfosuccinimidyl (4-iodoacetyl)aminobenzoate)

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker composed of sulfo-NHS-ester and iodoacetyl (haloacetyl) groups at ends of a 9-atom spacer arm.

11

Thermo Scientific™ Sulfo-MBS (m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester)

Crosslink amines to sulfhydryls with this short, water-soluble crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of an aromatic, 6-atom (7.3A) spacer arm.

12

Thermo Scientific™ Mass Spectrometry Compatible Crosslinkers

Improve mass spectrometry detection of crosslinked proteins and interactions with DSPP and TBDSPP heterotrifunctional crosslinkers.

Content And Storage Upon receipt store at -20°C protected from moisture.
Format Standard
Cleavable No
Product Type Crosslinker
Form Solid
Reactive Moiety NHS Ester
Spacer Arm Length 4.3 Å
Quantity 50 mg
Labeling Method Chemical Labeling
Crosslinker Type Homotrifunctional
Chemical Reactivity Amine-Amine
Product Line MS Reagents
PEGylated No
13

Thermo Scientific™ Pierce™ SMCC

No-Weigh™ Format

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 334.32
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability Yes
Format Standard, Single-use
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 8.3 Å
PEGylated No
14

Thermo Scientific™ Pierce™ Premium Grade Sulfo-NHS (N-hydroxysulfosuccinimide)

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this N-hydroxysuccinimide modification reagent.

Shipping Condition Ambient
Content And Storage Upon receipt store at 4°C.
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 217.13
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Carboxyl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Carbodiimide
Product Line Pierce
PEGylated No
15

Thermo Scientific™ SMPB (succinimidyl 4-(p-maleimidophenyl)butyrate)

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of NHS-ester and maleimide groups at ends of an aromatic, 10-atom (11.6A) spacer arm.