Protein Modification Reagents

Chemical agents used to modify the amino acid side chains of proteins in order to alter their native charges, block or expose reactive binding sites, inactivate functional groups, and change functional groups to create targets for crosslinking and labeling.

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Thermo Scientific™ CA(PEG)8 Carboxy-PEG-Amine Compound

CA(PEG)n: pegylated amino acids of the form carboxy-PEG-amine; with 4 to 24 polyethylene glycol units; for surface- and molecule-pegylation applications.

Pricing and Availability
Specifications

Content And Storage	Store desiccated at 4°C. Shipped at ambient temperature.
Product Type	Amine Compound
Spacer	8 ethylene glycol units
Solubility	Water
Reactive Moiety	Amine, Carboxylic Acid, Primary Amine
Label Type	Conjugating Groups, Polyethylene Glycol (PEG)

Thermo Scientific™ MS(PEG)12 Methyl-PEG-NHS-Ester Reagent

Pegylate amines (-NH2 groups) on proteins (lysine residues) or assay surfaces using MS(PEG)n, amine-reactive (NHS ester), methyl-capped PEG compounds (4 to 24 EG units).

Pricing and Availability
Specifications

Content And Storage	Store desiccated at -20°C.
Product Type	NHS-Ester Reagent
Spacer	12 ethylene glycol units
Solubility	Water
Reactive Moiety	Active Ester, Succinimidyl Ester, NHS Ester
Label Type	Polyethylene Glycol (PEG), Blocking Groups
Chemical Reactivity	Amine

Thermo Scientific™ MM(PEG)24 Methyl-PEG-Maleimide Reagent

Pegylate sulfhydryls (-SH groups) on proteins (cysteine residues) or assay surfaces using MS(PEG); sulfhydryl-reactive (maleimide), PEG compounds (12 and 24 EG units).

Pricing and Availability

Thermo Scientific™ Immobilized Trypsin, TPCK Treated (Agarose Resin)

Cleave the carboxyl-side of Arg and Lys residues with trypsin that isTPCK-treated to block chymotrypsin activity; its immobilized form allows enzyme removal after digestion.

Pricing and Availability

Thermo Scientific™ CA(PEG)24 Carboxy-PEG-Amine Compound

CA(PEG)n: pegylated amino acids of the form carboxy-PEG-amine; with 4 to 24 polyethylene glycol units; for surface- and molecule-pegylation applications.

Pricing and Availability
Specifications

Content And Storage	Store desiccated at 4°C. Shipped at ambient temperature.
Product Type	Amine Compound
Spacer	24 ethylene glycol units
Solubility	Water
Reactive Moiety	Amine, Carboxylic Acid, Primary Amine
Label Type	Conjugating Groups, Polyethylene Glycol (PEG)

MilliporeSigma™ Novagen™ Overnight Express™ Autoinduction System 1

Induces protein expression without monitoring cell density.

Pricing and Availability
Specifications

Content And Storage	15°C to 30°C

Thermo Scientific™ Pierce™ HRV 3C Protease Solution Kit (2 units/μL)

Remove fusion tags from proteins with the HRV 3C cleavage sequence with this recombinant cysteine protease that is dual tagged for easy removal from the sample after cleavage.

Pricing and Availability
Specifications

Content And Storage	Store at -20°C.
Product Type	Protease
Form	Kit
Product Line	Pierce

Gibco™ PNGase F Glycan Cleavage Kit

PNGase F Glycan Cleavage Kit includes all components necessary to perform the enzymatic removal of almost all N-linked oligosaccharides from glycoproteins.

Pricing and Availability

Invitrogen™ Thiol and Sulfide Quantitation Kit

Ultrasensitive colorimetric assay for quantifying both protein and nonprotein thiols

Pricing and Availability

Thermo Scientific™ Pierce™ Traut's Reagent (2-iminothiolane)

2-Iminothiolane-HCl (CAS 4781-83-3); an amine-reactive thiolation reagent to cap protein primary amines with sulfhydryl groups for immediate crosslinking.