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Substrates

Substrates are laboratory reagents, chemicals, and consumables, and kits used to support or enhance biomedical, pharmaceutical, clinical, food science, environmental, and other research and testing laboratory processes. Products include enzymes, inhibitors, acids, bases, buffers, antibodies, and chromatography supplies.
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1

Thermo Scientific™ CDK7/9tide Substrate  DFS Item

A peptide substrate based upon the C-terminal tail of RNA Polymerase II that is a reported substrate for Cyclin Dependent Kinases (CDK7, CDK8 and CDK9).

2

Thermo Scientific™ ZIPtide Substrate  DFS Item

A peptide substrate for the Ca/Calmodulin-dependent protein kinase (CaM) family including CAMK1 and DAPK1.

3

Thermo Scientific™ PI:PS Lipid Kinase Substrate  DFS Item

Specifically optimized for use with the Class III PI3 kinase (PIK3C3 (hVPS34)) and Type III PI4 lipid kinases, this substrate can also be used as a general substrate for the Class I lipid kinases.

4

CCF4-AM  DFS Item

CCF4-AM

Shipping Condition Room Temperature
Substrate CCF4-AM
Cell Permeability Cell-Permeant
Substrate Properties Chemical Substrate
Content And Storage Store in freezer (-5 to -30°C).
For Use With (Equipment) Flow Cytometer, Microplate Reader
Form Solid
Substrate Type Beta-Lactamase Substrate
Detection Method Fluorescence
5

Thermo Scientific™ Vivid™ EOMCC Substrate  DFS Item

Vivid™ Substrates are blocked dyes that yield a minimal fluorescence signal until oxidation occurs.

Shipping Condition Approved for shipment on Wet or Dry Ice
Substrate EOMCC
Substrate Properties Chemical Substrate
Content And Storage Vivid™ CYP450 Screening kits include:
• Vivid™ CYP450 Fluorogenic substrates (also available separately)
• BACULOSOMES™ CYP450 reagents
• Fluorescent standards
• NADPH-regeneration system

Store reaction buffers at +4°C or room temperature. Store BACULOSOMES™, the NADPH-regeneration system, and NADP+ at -80°C. Store the Vivid™ substrates and standards at +4°C, protected from light. (For long-term storage, resuspend in organic solvent and keep at -20°C.)
Substrate Type Cytochrome P450 Substrate
Product Line VIVID
Detection Method Fluorescence
6

Invitrogen™ DQ™ Ovalbumin - Special Packaging  DFS Item

Suited for antigen processing and presentation studies

7

Invitrogen™ MUP (4-Methylumbelliferyl Phosphate, Free Acid)  DFS Item

MUP is a fluorescent substrate for alkaline phosphatases

9

Invitrogen™ PFB-FDGlu (5-(Pentafluorobenzoylamino)Fluorescein Di-β-D-Glucopyranoside)  DFS Item

PFB-FDGlu is a cell-permeable substrate used for live cell imaging of GCase activity. It fluoresces green upon cleavage by lysosomal GCase, facilitating specific, single-cell analysis via high-content imaging, flow cytometry, and microscopy.

10

Thermo Scientific™ Fluorescein-PKC Substrate  DFS Item

A fluorescein-labeled peptide substrate for the Protein Kinase C (PKC) family.

12

Thermo Scientific™ LanthaScreen™ Tb-DUB Substrate  DFS Item

Deubiquitinating enzymes (DUBs) play housekeeping functions by maintaining pools of active ubiquitin, and regulatory function by rescuing specific target proteins from degradation by the proteasome.

13

Thermo Scientific™ GFP-4E-BP1  DFS Item

4E-BP1 expressed as a fusion with GFP (Green Fluorescent Protein) to act as a physiological substrate for FRAP1 (mTor).

15

MilliporeSigma™ Calbiochem™ Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride

Used as substrate for fluorogenic assay of plasma and glandular kallikreins. MilliporeSigma™; Calbiochem™ Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride also acts as substrate for cathepsin B, cathepsin L, and papain.