Used as substrate for fluorogenic assay of plasma and glandular kallikreins. MilliporeSigma™; Calbiochem™ Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride also acts as substrate for cathepsin B, cathepsin L, and papain.
Specifically optimized for use with the Class I PI3 kinases (PIK3CA, PIK3CB, PIK3CD, and PIK3CG), this substrate consists of lipid vesicles of a 1:19 molar ratio of phosphoinositol-4,5-bisphosphate (PIP2) with phosphotidylserine (PS).
PFB-FDGlu is a cell-permeable substrate used for live cell imaging of GCase activity. It fluoresces green upon cleavage by lysosomal GCase, facilitating specific, single-cell analysis via high-content imaging, flow cytometry, and microscopy.
Deubiquitinating enzymes (DUBs) play housekeeping functions by maintaining pools of active ubiquitin, and regulatory function by rescuing specific target proteins from degradation by the proteasome.