Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ PP2
PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC50 = 4, 5, 5, & 100 nM for p56lck, p59fynT, Hck, & Src, respectively).
MilliporeSigma™ Calbiochem™ α-Amyloid Precursor Protein Modulator
A cell-permeable benzolactam derived PKC activator (K
MilliporeSigma™ Calbiochem™ InSolution™ Smoothened Agonist, SAG
InSolution™ Smoothened Agonist, SAG, is a 10 mM (500 μg/86 μl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H2O.
MilliporeSigma™ Calbiochem™ STAT3 Inhibitor III, WP1066
STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent.
MilliporeSigma™ Calbiochem™ STAT5 Inhibitor III, Pimozide
The STAT5 Inhibitor III, Pimozide, also referenced under CAS 2062-78-4, controls the biological activity of STAT5.
MilliporeSigma™ Calbiochem™ Purmorphamine
A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 μM).
MilliporeSigma™ Calbiochem™ TLR4 Inhibitor, TAK-242
TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.
MilliporeSigma™ Calbiochem™ InSolution™ Staurosporine, Streptomyces sp.
InSolution™ Staurosporine, Streptomyces sp. CAS 62996-74-1, is provided as a 1mm (100μg/214μl) solution of Staurosporine (Cat. No. 569397) in DMSO
MilliporeSigma™ Calbiochem™ CMP-Sialic Acid, Disodium Salt InSolution™
A 25 mM (10 mg/608 μL) sterile-filtered solution of CMP-Sialic Acid, Disodium Salt in H2O.
MilliporeSigma™ Calbiochem™ TRPV4 Agonist, GSK1016790A
A cell-permeable, potent, selective agonist of TRPV4 channel. Enhances Ca2+ flux in a variety of human and mouse cells (EC50 = 2.1 nM for human TRPV4).
MilliporeSigma™ Calbiochem™ Ru360
A cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM).
MilliporeSigma™ Calbiochem™ InSolution™ Aphidicolin
A 30 mM (1 mg/98 μL) sterile-filtered solution of Aphidicolin in DMSO.
MilliporeSigma™ Calbiochem™ TLR3/dsRNA Complex Inhibitor
The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.
MilliporeSigma™ Calbiochem™ Granzyme B Inhibitor I
The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
