Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Wnt Antagonist I, IWR-1-endo
Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC50 = 131 nM) & TNKS2/PARP5b (IC50≥ 56 nM). Suppress Wnt-stimulated transcription activity (IC50 = 180 nM).
Thermo Scientific Chemicals Oxymetazoline hydrochloride
CAS: 2315-02-8 Molecular Formula: C16H25ClN2O
MilliporeSigma™ Calbiochem™ PKCζ Pseudosubstrate Inhibitor, Myristoylated
PKCζ Pseudosubstrate Inhibitor is a myristoylated, cell-permeable, reversible, substrate competitive inhibitor of protein kinase Cζ.
MilliporeSigma™ Calbiochem™ InSolution™ γ-Secretase Inhibitor X
InSolution™ γ-Secretase Inhibitor X is a 1 mM solution in DMSO. A highly potent inhibitor of g-secretase (IC50 = 17, 48, 67 nM for Aβtotal, Aβ40 & Aβ42 in SHSY5Y cells overexpressing spβA4CTF).
MilliporeSigma™ Calbiochem™ Cdk1 Inhibitor IV, RO-3306
RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively).
MilliporeSigma™ Calbiochem™ Genistein, Soybean
A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 μM).
MilliporeSigma™ Calbiochem™ EPAC Inhibitor, ESI-09
A cell-permeable compound that targets cAMP-binding domain of EPAC/cAMP-GEF and inhibits cAMP-dependent EPAC GEF activity (IC50 = 1.4 and 3.2 μM, respectively, against EPAC2 and EPAC1).
MilliporeSigma™ Calbiochem™ Emetine, Dihydrochloride
Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.
MilliporeSigma™ Calbiochem™ Cisplatin
Reported to sensitize glioma cells to TNF-α-induced apoptosis.
MilliporeSigma™ Calbiochem™ Conduritol B Epoxide
Conduritol B Epoxide, CAS 6090-95-5, is an irreversible Inhibitor of glucocerebrosidase in neurons. Also inhibits α-glucosidase activity in a variety of species.
MilliporeSigma™ Calbiochem™ Substance P
Neuropeptide found in high concentrations in the gut.
MilliporeSigma™ Calbiochem™ Beclin-1 Activator II, retro-inverso TAT-Beclin-1
A cell-permeable, all-D-amino acid autophagy-inducing peptide.
MilliporeSigma™ Calbiochem™ L-(–)-Norepinephrine-(+)-bitartrate
α,β-Adrenergic agonist.
MilliporeSigma™ Calbiochem™ GSK-3 Inhibitor XVI
GSK-3 Inhibitor XVI - CAS 252917-06-9, is a cell-permeable, potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively).
MilliporeSigma™ Calbiochem™ Berberine Chloride
A highly potent and selective oxysterol EBI2 (GPR183) agonist (K