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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1

Thermo Scientific™ BM(PEG)2 (1,8-bismaleimido-diethyleneglycol)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, pegylated, water-soluble crosslinker composed of maleimide groups and 2-unit (14.7A) PEG spacer arm.

2

Thermo Scientific™ Sulfo-MBS (m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester)

Crosslink amines to sulfhydryls with this short, water-soluble crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of an aromatic, 6-atom (7.3A) spacer arm.

3

Thermo Scientific™ Pierce™ Premium Grade Sulfo-NHS (N-hydroxysulfosuccinimide)

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this N-hydroxysuccinimide modification reagent.

Shipping Condition Ambient
Content And Storage Upon receipt store at 4°C.
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 217.13
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Carboxyl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Carbodiimide
Product Line Pierce
PEGylated No
4

Thermo Scientific™ Sulfo-NHS (N-hydroxysulfosuccinimide), No-Weigh™ Format

Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Molecular Weight (g/mol) 217.13
Solubility Water
PEGylated No
5

Thermo Scientific™ Pierce™ EDC, No-Weigh™ Format

Immobilize or conjugate proteins using 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (CAS 25952-53-8), a water-soluble, carboxyl-to-amine crosslinker.

Shipping Condition Wet Ice
Content And Storage Upon receipt store desiccated at -20°C.
Description EDC
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 191.7
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Carboxyl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Carbodiimide
Spacer Arm Length 0.0 Å
PEGylated No
6

Thermo Scientific™ Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)

Crosslink amines to sulfhydryls with this mid-length crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of a water-soluble, 8-atom (9.4A) spacer arm.

7

Thermo Scientific™ Pierce™ Premium Grade EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride)

Optimize applications where product integrity and risk minimization are paramount with this high-quality formulation of carbodiimide crosslinker.

Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 191.7
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Carboxyl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Carbodiimide
Spacer Arm Length 0.0 Å
Product Line Pierce
PEGylated No
8

Thermo Scientific™ Sulfo-SMCC (sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate), No-Weigh™ Format

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Description Sulfo-SMCC
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 436.37
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Maleimide, Sulfo-NHS Ester
Spacer Arm Length 8.3 Å
PEGylated No
9

Thermo Scientific™ Pierce™ Premium Grade DSP (dithiobis(succinimidyl propionate))

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this popular amine-reactive, cleavable crosslinker.

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 404.42
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Formulation Dithiobis(succinimidylpropionate); powder solid
Reactive Moiety NHS Ester
Spacer Arm Length 12.0 Å
Product Line Pierce
PEGylated No
10

Thermo Scientific™ NHS (N-hydroxysuccinimide)

Prepare amine-reactive NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysuccinimide, CAS 6066-82-6.

11

Thermo Scientific™ Mass Spectrometry Cleavable Crosslinkers

Improve sensitivity of mass spectrometry detection of crosslinked proteins with MS-cleavable DSSO and DSBU heterotrifunctional crosslinkers.

Content And Storage Upon receipt store at 4°C protected from moisture.
Cleavable By CID using MS
Water Soluble No
Form Powder
Solubility DMF, DMSO
Quantity 10 x 1 mg
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety NHS Ester
PEGylated No
12

Thermo Scientific™ Pierce™ DSG, No-Weigh™ Format

Cleavable No
Water Soluble No
Form Powder
Molecular Weight (g/mol) 326.26
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety NHS Ester
Spacer Arm Length 7.7 Å
PEGylated No
13

Thermo Scientific™ MBS (m-maleimidobenzoyl-N-hydroxysuccinimide ester)

Crosslink amines to sulfhydryls with this short crosslinker composed of NHS-ester and maleimide groups at ends of an aromatic, 6-atom (7.3A) spacer arm.

14

Thermo Scientific™ SM(PEG)6 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

15

Thermo Scientific™ DTSSP (3,3'-dithiobis(sulfosuccinimidyl propionate))

Crosslink amines to amines with Sulfo-DSP; composed of sulfo-NHS-ester groups and disulfide spacer arm (12.0A) that is cleavable with reducing agents.