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Protein Purification

Kits, columns, gels, reagents, enzymes, inhibitors, and other assorted products for use with protein purification procedures.
Protein Purification Reagents and Kits (674)
Protease Inhibitors and Phosphatase Inhibitors (282)
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1 – 15 of 955 results
1

MilliporeSigma™ Calbiochem™ Hydroxychloroquine Sulfate

A cell-permeable compound that increases intralysosomal pH and impairs autophagic degradation process. Suppresses proliferation of human dermal fibroblasts (IC50 = 30 μM).

2

MilliporeSigma™ Calbiochem™ HSP70 Inhibitor, PES-Cl

Directly binds to HSP70 and disrupts its interaction with client proteins..

3

MilliporeSigma™ Calbiochem™ Roscovitine

A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater efficacy towards p33-cdk5 relative to Olomoucine.

CAS 186692-46-6
Form Solid
Target Proteins p34cdk1/cyclin B
Solubility DMSO
Color White to Off-white
Purity 95% by HPLC
Molecular Formula C19H26N6O
Formula Weight 354.5g/mol
4

MilliporeSigma™ Calbiochem™ NAE Inhibitor, MLN4924

NAE Inhibitor, MLN4924, CAS 951950-33-7, is an AMP mimetic that forms a NAE-catalyzed NEDD8 adduct, which acts as a tight-binding, ATP-competitive NAE inhibitor (IC50 = 4.7nM).

5

MilliporeSigma™ Calbiochem™ Lactimidomycin

Lactimidomycin, CAS 134869-15-1, inhibits cell migration, proliferation, & protein synthesis (IC50 = 37.8nM). Blocks the first translocation step and has no effect on tRNA binding.

6

MilliporeSigma™ Calbiochem™ ACE2 Inhibitor, MLN-4760

A cell-permeable, highly potent inhibitor of angiotensin converting enzyme 2 (ACE2; IC50 = 440 pM).

7

MilliporeSigma™ Calbiochem™ Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride

Chemically-modified forskolin with greater stability and water solubility than the parent compound.

Content And Storage Hygroscopic
CAS 115116-37-5
Form Solid
Target Proteins Adenylate cyclase
Solubility MeOH or H2O
Color White
Purity 92% by HPLC
Molecular Formula C29H48N2O7·2HCl
Formula Weight 609.6g/mol
8

MilliporeSigma™ Calbiochem™ Smoothened Agonist, SAG

A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).

Content And Storage Hygroscopic, Protect from light
CAS 364590-63-6
Form Solid
Solubility DMSO or H2O
Color Light Yellow
Purity 98% by HPLC
Molecular Formula C28H28ClN3OS·2HCl·2H2O
Formula Weight 599g/mol
9

MilliporeSigma™ Calbiochem™ mTOR Inhibitor XI, Torin1

mTOR Inhibitor XI, Torin1, CAS 1222998-36-8, is a cell-permeable, highly potent, ATP-competitive inhibitor of mTOR and DNA-PK (IC50 = 4.32 and 6.34 nM, respectively).

10

MilliporeSigma™ Calbiochem™ MEK1/2 Inhibitor III

The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

12

MilliporeSigma™ Calbiochem™ NF-κB SN50, Cell-Permeable Inhibitor Peptide

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

Content And Storage Hygroscopic
Form Lyophilized
Target Proteins translocation of the NF-κB active complex into the nucleus
Formulation Supplied as a trifluoroacetate salt.
Solubility H2O
Purity 97% by HPLC
Molecular Formula C129H230N36O29S
Formula Weight 2781.5g/mol
14

MilliporeSigma™ Calbiochem™ InSolution™Blebbistatin, Racemic

InSolution™Blebbistatin, Racemic, is a 50mm in 90% DMSO. A cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration and cytoKinesis.

15

MilliporeSigma™ Calbiochem™ Furin Inhibitor I

Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.