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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1

Thermo Scientific™ Pierce™ Premium Grade Sulfo-NHS (N-hydroxysulfosuccinimide)

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this N-hydroxysuccinimide modification reagent.

Shipping Condition Ambient
Content And Storage Upon receipt store at 4°C.
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 217.13
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Carboxyl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Carbodiimide
Product Line Pierce
PEGylated No
2

Thermo Scientific™ TSAT (tris-(succinimidyl)aminotriacetate)

A 3-way, short-arm (4.2A) amine-to-amine crosslinker; tris (succinimidyl) aminotriacetate, composed of three NHS-ester groups on short spacer arms; membrane permeable.

3

Thermo Scientific™ SDA (NHS-Diazirine) (succinimidyl 4,4'-azipentanoate)

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

4

Thermo Scientific™ LC-SDA (NHS-LC-Diazirine) (succinimidyl 6-(4,4'-azipentanamido)hexanoate)

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

5

Thermo Scientific™ SM(PEG)8 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

6

Thermo Scientific™ BMPH (N-β-maleimidopropionic acid hydrazide)

Crosslink sulfhydryls to periodate-treated glycoprotein sugars with this short (8.1A) crosslinker containing maleimide and hydrazide groups.

7

Thermo Scientific™ PEG12-SPDP (PEGylated, long-chain SPDP crosslinker)

Very long (54.1A) amine-to-sulfhydryl crosslinker; NHS-ester and pyridyldithiol groups at ends of 12-unit polyethylene glycol spacer arm; forms cleavable disulfide bonds; water-soluble.

8

Thermo Scientific™ SPB (succinimidyl-[4-(psoralen-8-yloxy)]-butyrate)

Crosslink amines to DNA with this crosslinker composed of NHS-ester and psoralen reactive groups; conjugates to DNA via light-activated intercalation next to pyrimidine bases.

9

Thermo Scientific Pierce™ Pierce™ SM(PEG)2, No-Weigh™ Format

Thermo Scientific™ Pierce™ SM(PEG)2 is hetero-bifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.

10

Thermo Scientific™ DTBP (Wang and Richard's Reagent)

Crosslink amines to amines with dithiobispropionimidate; composed of imidoester groups at either end of a reducible (cleavable) disulfide-containing spacer arm.

11

Thermo Scientific™ Pierce™ SMCC

No-Weigh™ Format

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 334.32
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability Yes
Format Standard, Single-use
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 8.3 Å
PEGylated No
12

Thermo Scientific™ EGS (ethylene glycol bis(succinimidyl succinate))

Crosslink amines to amines with this membrane permeable crosslinker composed of NHS-ester groups and a 16.1A hydroxylamine-cleavable spacer arm.

13

Thermo Scientific™ Sulfo-EGS (ethylene glycol bis(sulfosuccinimidyl succinate))

Crosslink amines to amines with a crosslinker composed of sulfo-NHS-ester groups and hydroxylamine-cleavable spacer arm; water-soluble for cell-surface protein crosslinking.

14

Thermo Scientific™ EMCH (N-ε-maleimidocaproic acid hydrazide)

Crosslink sulfhydryls to periodate-treated glycoprotein sugars with this mid-length (11.8A) crosslinker containing maleimide and hydrazide groups.

15

Thermo Scientific™ SM(PEG)24 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).