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Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Keyword Search:
1 – 15 of 883 results
1

Tocris Bioscience™ BIX NHE1 inhibitor

Potent and selective NHE1 inhibitor

Target Na+/Ca2+ Exchanger Inhibitors
CAS 1422252-46-7
Purity >98%
Chemical Name or Material 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride
Recommended Storage Desiccate at Room Temperature
Molecular Formula C16H19F3N4O2.HCl
Formula Weight 392.8
2

Tocris Bioscience™ PLpro inhibitor 6

SARS-CoV and SARS-CoV-2 PLpro inhibitor

Target Papain-like Protease Inhibitors
CAS 1093070-14-4
Purity 0.98
Chemical Name or Material 5-(Acetylamino)-2-methyl-N-[(1 R)-1-(1-naphthalenyl)ethyl]benzamide
Recommended Storage Store at -20°C
Molecular Formula C22H22N2O2
3

Tocris Bioscience™ RIPK2 inhibitor 1

Potent RIPK2 inhibitor

Target RIP Kinase Inhibitors
CAS 1290490-78-6
Chemical Name or Material 3-(Benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide
Recommended Storage Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Molecular Formula C25H22N4O2
4

Tocris Bioscience™ O8 OGG1 Inhibitor

Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay)

CAS 350997-39-6
Purity 98%
Chemical Name or Material 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
Recommended Storage Store at 4°C
Molecular Formula C9H6Cl2N2OS
Formula Weight 261.13
5

Tocris Bioscience™ TM2 TEAD inhibitor

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

Target YAP1
CAS 1008768-41-9
Purity 0.98
Chemical Name or Material 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
Recommended Storage Store at -20°C
Molecular Formula C26H33N3O3
6

Tocris Bioscience™ IRAK1/4 Inhibitor I

IRAK4 and IRAK1 inhibitor

Target Other Kinase Inhibitors
CAS 509093-47-4
Purity >98%
Chemical Name or Material N-[1-[2-(4-Morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitrobenzamide
Recommended Storage Store at -20°C
Molecular Formula C20H21N5O4
Formula Weight 395.41
7

Tocris Bioscience™ MI 2 (MALT1 inhibitor)

CAS: 1047953-91-2 Molecular Formula: C19H17Cl3N4O3

CAS 1047953-91-2
Molecular Formula C19H17Cl3N4O3
8

Tocris Bioscience™ AZ1 USP25/28 inhibitor

Selective USP25 and USP28 inhibitor

Target USP28
CAS 2165322-94-9
Purity 0.98
Chemical Name or Material 2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol
Recommended Storage Store at -20°C
Molecular Formula C17H16BrF4NO2
9

Tocris Bioscience™ AKT Inhibitor IV

Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates

10

Tocris Bioscience™ PLpro inhibitor 19

SARS-CoV-2 PLpro and replication inhibitor

11

Invitrogen™ Thapsigargin  DFS Item

Tumor promoter

Shipping Condition Room Temperature
Product Type Inhibitor
Recommended Storage Store in freezer (-5°C to -30°C)
Molecular Formula C34H50O12
Label Type Unlabeled
12

Invitrogen™ eBioscience™ Brefeldin A Solution (1000X)

Addition of Brefeldin A during the last hours of in vitro activation of cells results in enhanced detection of intracellular cytokines.

13

Invitrogen™ eBioscience™ Monensin Solution (1000X)

Addition of Monensin during the last hours of in vitro activation of cells results in enhanced detection of intracellular cytokines.

14

Invitrogen™ Latrunculin A  DFS Item

For applications involving cell structure

15

Invitrogen™ Pepstatin A, BODIPY™ FL Conjugate  DFS Item

For the study of cathepsin D trafficking in cells by fluorescence microscopy