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Signal Transduction Reagents and Kits

Kits, assays, systems, reagents, inhibitors, and a variety of other products for use in the study of cellular signal transduction pathways.
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1 – 15 of 32 results
1

Promega Cell Permeable Inhibitors  DFS Item

LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases (PI 3-kinases).

2

Thermo Scientific Chemicals MIF Antagonist, ISO-1

CAS: 478336-92-4 Molecular Formula: C12H13NO4,C12H13NO4 Synonym: (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester; Macrophage Migration Inhibitory Factor Antagonist

CAS 478336-92-4
Synonym (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester; Macrophage Migration Inhibitory Factor Antagonist
Molecular Formula C12H13NO4,C12H13NO4
3

Promega cAMP-Glo™ Assay  DFS Item

The cAMP-Glo™ Assay is a homogeneous, bioluminescent and high-throughput assay for measuring cAMP levels in cells

Content And Storage -30°C to -10°C
Format 384-well Plate
For Use With (Equipment) For 384-well plates
For Use With (Application) For high throughput analysis of library compounds to identify modulators of GPCR activity
4

Thermo Scientific Chemicals GSK-3beta Inhibitor VIII

CAS: 487021-52-3 Molecular Formula: C12H12N4O4S,C12H12N4O4S Molecular Weight (g/mol): 308.31 InChI Key: YAEMHJKFIIIULI-UHFFFAOYSA-N Synonym: AR-A014418 IUPAC Name: 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea SMILES: COC1=CC=C(CNC(=O)NC2=NC=C(S2)[N+]([O-])=O)C=C1

CAS 487021-52-3
Molecular Weight (g/mol) 308.31
SMILES COC1=CC=C(CNC(=O)NC2=NC=C(S2)[N+]([O-])=O)C=C1
Synonym AR-A014418
IUPAC Name 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea
InChI Key YAEMHJKFIIIULI-UHFFFAOYSA-N
Molecular Formula C12H12N4O4S,C12H12N4O4S
5

Thermo Scientific Chemicals DNA Methyltransferase Inhibitor

CAS: 48208-26-0 Molecular Formula: C19H14N2O4,C19H14N2O4 Molecular Weight (g/mol): 334.33 InChI Key: HPTXLHAHLXOAKV-UHFFFAOYNA-N Synonym: RG108; N-Phthalyl-L-tryptophan IUPAC Name: 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid SMILES: OC(=O)C(CC1=CNC2=CC=CC=C12)N1C(=O)C2=CC=CC=C2C1=O

CAS 48208-26-0
Molecular Weight (g/mol) 334.33
SMILES OC(=O)C(CC1=CNC2=CC=CC=C12)N1C(=O)C2=CC=CC=C2C1=O
Synonym RG108; N-Phthalyl-L-tryptophan
IUPAC Name 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
InChI Key HPTXLHAHLXOAKV-UHFFFAOYNA-N
Molecular Formula C19H14N2O4,C19H14N2O4
6

Thermo Scientific Chemicals RITA, p53 activator III

CAS: 213261-59-7 Molecular Formula: C14H12O3S2,C14H12O3S2 Synonym: 5,5′-(2,5-Furandiyl)bis-2-thiophenemethanol; NSC 652287

CAS 213261-59-7
Synonym 5,5′-(2,5-Furandiyl)bis-2-thiophenemethanol; NSC 652287
Molecular Formula C14H12O3S2,C14H12O3S2
7

Thermo Scientific Chemicals Sirtinol

CAS: 410536-97-9 Molecular Formula: C26H22N2O2,C26H22N2O2 Molecular Weight (g/mol): 394.47 InChI Key: YUGODMKHHCZZOI-ZVTCDHROSA-N Synonym: (E)-2-((2-Hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide IUPAC Name: 2-({[(1Z)-2-oxo-1,2-dihydronaphthalen-1-ylidene]methyl}amino)-N-[(1S)-1-phenylethyl]benzamide SMILES: C[C@H](NC(=O)C1=CC=CC=C1N\C=C1/C(=O)C=CC2=CC=CC=C12)C1=CC=CC=C1

CAS 410536-97-9
Molecular Weight (g/mol) 394.47
SMILES C[C@H](NC(=O)C1=CC=CC=C1N\C=C1/C(=O)C=CC2=CC=CC=C12)C1=CC=CC=C1
Synonym (E)-2-((2-Hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide
IUPAC Name 2-({[(1Z)-2-oxo-1,2-dihydronaphthalen-1-ylidene]methyl}amino)-N-[(1S)-1-phenylethyl]benzamide
InChI Key YUGODMKHHCZZOI-ZVTCDHROSA-N
Molecular Formula C26H22N2O2,C26H22N2O2
8

Thermo Scientific Chemicals Aphidicolin

CAS: 38966-21-1 Molecular Formula: C20H34O4,C20H34O4 Synonym: APC

CAS 38966-21-1
Synonym APC
Molecular Formula C20H34O4,C20H34O4
9

Thermo Scientific Chemicals Autophagy Inhibitor, 3-MA

CAS: 5142-23-4 Molecular Formula: C6H7N5,C6H7N5 Synonym: 3-Methyladenine; 6-Amino-3-methylpurine

CAS 5142-23-4
Synonym 3-Methyladenine; 6-Amino-3-methylpurine
Molecular Formula C6H7N5,C6H7N5
10

Thermo Scientific Chemicals N-Acetyl-D-sphingosine, 98%

CAS: 3102-57-6 Molecular Formula: C20H39NO3,C20H39NO3 Synonym: Acetyl ceramide; C2-Ceramide

CAS 3102-57-6
Synonym Acetyl ceramide; C2-Ceramide
Molecular Formula C20H39NO3,C20H39NO3
11

Promega ONE-Glo™ Assay  DFS Item

The ONE-Glo™ + Tox Assay combines luciferase assay chemistry with a cell viability marker to better understand reporter gene expression in the context of cell health. The assay uses a two-step, addition-only process to measure in a single well of a plate.

Content And Storage -30°C to -10°C
Form Fluid
pH 7.5
12

Thermo Scientific Chemicals Compound E

CAS: 209986-17-4 Molecular Formula: C27H24F2N4O3 Synonym: γ-Secretase Inhibitor XXI;

CAS 209986-17-4
Synonym γ-Secretase Inhibitor XXI;
Molecular Formula C27H24F2N4O3
13

Thermo Scientific Chemicals Evodiamine

CAS: 518-17-2 Molecular Formula: C19H17N3O,C19H17N3O

CAS 518-17-2
Molecular Formula C19H17N3O,C19H17N3O
14

Thermo Scientific Chemicals Syk Inhibitor

CAS: 622387-85-3 Molecular Formula: C18H15N3O3S,C18H15N3O3S Synonym: Spleen Tyrosine Kinase Inhibitor

CAS 622387-85-3
Synonym Spleen Tyrosine Kinase Inhibitor
Molecular Formula C18H15N3O3S,C18H15N3O3S
15

Thermo Scientific Chemicals Lck Inhibitor II

CAS: 918870-43-6 Molecular Formula: C24H26N6O3 Synonym: 3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)-pyrimidin-4-ylamino)-4-methylphenol;

CAS 918870-43-6
Synonym 3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)-pyrimidin-4-ylamino)-4-methylphenol;
Molecular Formula C24H26N6O3