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Vivid™ BOMCC Substrate DFS Item

Vivid™ BOMCC Substrate

Manufacturer:  Life Technologies LSP2980

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Catalog No. P2980



Description

Description

Vivid™ Substrates are blocked dyes that yield a minimal fluorescence signal until oxidation occurs. Cytochrome P450 metabolism at either of two potential oxidation sites releases the highly fluorescent product. They have superior fluorescence, solubility, and kinetic properties compared to conventional fluorogenic probes. This results in higher sensitivity, greater signal-to-noise ratio, and better assay reproducibility. When used in combination with CYP450 BACULOSOMES™ Plus Reagents as part of the Vivid™ CYP450 Screening Kits, the Vivid™ Substrates enable rapid, robust detection of cytochrome P450 inhibitors. This particular substrate (Vivid ™ BOMCC Substrate) yields a product that emits a blue fluorescence.

More About Vivid™ CYP450 Screening Kits
Vivid™ CYP450 Screening Kits are high-throughput fluorescence-based assays for detection of enzyme-drug interactions and CYP450 inhibition. Vivid™ CYP450 Screening Kits include Vivid™ Substrate, Vivid™ Fluorescent Standard, reaction buffer, Vivid™ Regeneration System, NADP+, and CYP450 BACULOSOMES™ Plus Reagent. CYP450 BACULOSOMES™ Plus Reagents are microsomes prepared from insect cells expressing a human CYP450 isozyme and human cytochrome P450 reductase. CYP450 BACULOSOMES™ Plus Reagents offer a distinct advantage over human liver microsomes in that only one CYP450 isozyme is expressed, thereby preventing metabolism by other CYP450s.

>> View all Vivid™ CYP450 Screening Kits

Applications: high-throughput screening of enzyme-drug interactions, compound profiling for drug inhibition of cytochrome P450 isozymes, generation of predictive SAR models to guide compound acquisition

For Research Use Only. Not for any animal or human therapeutic or diagnostic use.
Specifications

Specifications

Cell viability, proliferation and function, pharma and biopharma, protein assays and analysis, target-based ADME/Tox assays
307.3g/mol
Vivid™ BOMCC Substrate
Cytochrome P450 substrate
Vivid™ BOMCC Substrate, 1mg, 307.3g/mol Molecular Weight, ≥ 97% Purity, Cytochrome P450 Substrate Type, Fluorescent Detection Method, Used For Cell Viability, Proliferation and Function, Pharma and Biopharma, Protein Assays and Analysis, Target-Based ADME/Tox Assays
Vivid™ CYP450 fluorogenic substrates, BACULOSOMES™ CYP450 reagents, fluorescent standards, and an NADPH-regeneration system
1 Each
1mg
–20°C
Documents

For Research Use Only. Not for use in diagnostic procedures.