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Thermo Scientific Chemicals U-18666A, 95%
$196.86 - $338.25
Identifiants chimiques
| CAS | 3039-71-2 |
|---|---|
| Molecular Formula | C25H42ClNO2 |
| Synonym | 3β-[2-(Diethylamino)ethoxy]androstenone hydrochloride |
| Numéro de catalogue | Numéro du manufacturier. | Quantity | Prix | Quantity & Availability | |||||
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| Numéro de catalogue | Numéro du manufacturier. | Quantity | Prix | Quantity & Availability | |||||
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AAJ67389MA
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Thermo Scientific Chemicals
J67389MA |
10 mg |
chaque for $338.25
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Connectez-vous ou enregistrez-vous pour vérifier votre prix et la disponibilité.
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AAJ67389LB0
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Thermo Scientific Chemicals
J67389LB0 |
5 mg |
chaque for $196.86
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Connectez-vous ou enregistrez-vous pour vérifier votre prix et la disponibilité.
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Description
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Identifiants chimiques
| 3039-71-2 | |
| C25H42ClNO2 | |
| 3β-[2-(Diethylamino)ethoxy]androstenone hydrochloride |
Spécifications
| White to off-white | |
| 3039-71-2 | |
| 424.06 | |
| 195°C to 196.5°C | |
| U-18666A, 95% | |
| ICPRVJHNLABCSA-UHFFFAOYNA-N | |
| hydrogen 8-[2-(diethylamino)ethoxy]-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-one chloride | |
| 95% |
| 2°C to 8°C | |
| C25H42ClNO2 | |
| 3β-[2-(Diethylamino)ethoxy]androstenone hydrochloride | |
| Soluble in water at 10mg/ml | |
| Solid | |
| [H+].[Cl-].CCN(CC)CCOC1CCC2=CCC3C4CCC(=O)C4(C)CCC3C2(C)C1 | |
| 424.07 |
Sécurité et manipulation
Recommended Storage : Keep cold
RUO – Research Use Only