Signal Transduction Reagents and Kits

Kits, assays, systems, reagents, inhibitors, and a variety of other products for use in the study of cellular signal transduction pathways.

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Thermo Scientific™ SAG

CAS: 912545-86-9 Molecular Formula: C28H28ClN3OS,C28H28ClN3OS Molecular Weight (g/mol): 490.06 InChI Key: VFSUUTYAEQOIMW-UHFFFAOYSA-N Synonym: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]- benzo[b]thiophene-2-carboxamide; Smoothened Agonist IUPAC Name: 3-chloro-N-[4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide SMILES: CNC1CCC(CC1)N(CC1=CC(=CC=C1)C1=CC=NC=C1)C(=O)C1=C(Cl)C2=CC=CC=C2S1

Pricing and Availability
Specifications

CAS	912545-86-9
Molecular Weight (g/mol)	490.06
SMILES	CNC1CCC(CC1)N(CC1=CC(=CC=C1)C1=CC=NC=C1)C(=O)C1=C(Cl)C2=CC=CC=C2S1
Synonym	3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]- benzo[b]thiophene-2-carboxamide; Smoothened Agonist
IUPAC Name	3-chloro-N-[4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide
InChI Key	VFSUUTYAEQOIMW-UHFFFAOYSA-N
Molecular Formula	C28H28ClN3OS,C28H28ClN3OS

Thermo Scientific Chemicals Salubrinal

CAS: 405060-95-9 Molecular Formula: C21H17Cl3N4OS,C21H17Cl3N4OS Synonym: eIF-2alpha Inhibitor; SAL

Pricing and Availability
Specifications

CAS	405060-95-9
Synonym	eIF-2alpha Inhibitor; SAL
Molecular Formula	C21H17Cl3N4OS,C21H17Cl3N4OS

Thermo Scientific Chemicals Calpain Inhibitor XI

CAS: 145731-49-3 Molecular Formula: C26H40N4O6,C26H40N4O6 Synonym: Z-Leu-α-aminobutyric acid-CONH(CH2)3-morpholine; Z-L-Abu-CONH(CH2)3-morpholine

Pricing and Availability
Specifications

CAS	145731-49-3
Synonym	Z-Leu-α-aminobutyric acid-CONH(CH2)3-morpholine; Z-L-Abu-CONH(CH2)3-morpholine
Molecular Formula	C26H40N4O6,C26H40N4O6

Thermo Scientific Chemicals Aurora Kinase/Cdk Inhibitor

CAS: 443797-96-4 Molecular Formula: C15H12F2N6O3S,C15H12F2N6O3S Molecular Weight (g/mol): 394.36 InChI Key: KDKUVYLMPJIGKA-UHFFFAOYSA-N Synonym: 4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide; IUPAC Name: 4-{[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino}benzene-1-sulfonamide SMILES: NC1=NC(NC2=CC=C(C=C2)S(N)(=O)=O)=NN1C(=O)C1=C(F)C=CC=C1F

Pricing and Availability
Specifications

CAS	443797-96-4
Molecular Weight (g/mol)	394.36
SMILES	NC1=NC(NC2=CC=C(C=C2)S(N)(=O)=O)=NN1C(=O)C1=C(F)C=CC=C1F
Synonym	4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide;
IUPAC Name	4-{[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino}benzene-1-sulfonamide
InChI Key	KDKUVYLMPJIGKA-UHFFFAOYSA-N
Molecular Formula	C15H12F2N6O3S,C15H12F2N6O3S

Thermo Scientific Chemicals Z-Val-Val-Nle Diazomethyl Ketone

CAS: 155026-49-6 Molecular Formula: C25H37N5O5,C25H37N5O5 Molecular Weight (g/mol): 487.60 InChI Key: IIPZPLSBQVJCBO-UHFFFAOYNA-N Synonym: C-3890; Z-Val-Val-Nle-DMK IUPAC Name: benzyl N-[1-({1-[(1-diazo-2-oxoheptan-3-yl)carbamoyl]-2-methylpropyl}carbamoyl)-2-methylpropyl]carbamate SMILES: CCCCC(NC(=O)C(NC(=O)C(NC(=O)OCC1=CC=CC=C1)C(C)C)C(C)C)C(=O)C=[N+]=[N-]

Pricing and Availability
Specifications

CAS	155026-49-6
Molecular Weight (g/mol)	487.60
SMILES	CCCCC(NC(=O)C(NC(=O)C(NC(=O)OCC1=CC=CC=C1)C(C)C)C(C)C)C(=O)C=[N+]=[N-]
Synonym	C-3890; Z-Val-Val-Nle-DMK
IUPAC Name	benzyl N-[1-({1-[(1-diazo-2-oxoheptan-3-yl)carbamoyl]-2-methylpropyl}carbamoyl)-2-methylpropyl]carbamate
InChI Key	IIPZPLSBQVJCBO-UHFFFAOYNA-N
Molecular Formula	C25H37N5O5,C25H37N5O5

Thermo Scientific Chemicals Tioconazole, 98+%

CAS: 65899-73-2 Molecular Formula: C₁₆H₁₃Cl₃N₂OS Synonym: Thioconazole

Pricing and Availability
Specifications

CAS	65899-73-2
Synonym	Thioconazole
Molecular Formula	C₁₆H₁₃Cl₃N₂OS

Thermo Scientific Chemicals Z-Leu-Val-Gly Diazomethyl Ketone

CAS: 119670-30-3 Molecular Formula: C22H31N5O5,C22H31N5O5 Molecular Weight (g/mol): 445.52 InChI Key: ZLDBPOCJCXPVND-OALUTQOASA-N Synonym: C-3455 IUPAC Name: benzyl N-[(1S)-1-{[(2S)-2-[(3-diazo-2-oxopropyl)amino]-3-methylbutanoyl]carbamoyl}-3-methylbutyl]carbamate SMILES: CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)NC(=O)[C@@H](NCC(=O)C=[N+]=[N-])C(C)C

Pricing and Availability
Specifications

CAS	119670-30-3
Molecular Weight (g/mol)	445.52
SMILES	CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)NC(=O)[C@@H](NCC(=O)C=[N+]=[N-])C(C)C
Synonym	C-3455
IUPAC Name	benzyl N-[(1S)-1-{[(2S)-2-[(3-diazo-2-oxopropyl)amino]-3-methylbutanoyl]carbamoyl}-3-methylbutyl]carbamate
InChI Key	ZLDBPOCJCXPVND-OALUTQOASA-N
Molecular Formula	C22H31N5O5,C22H31N5O5

Thermo Scientific Chemicals Sulindac Sulfide

CAS: 32004-67-4 Molecular Formula: C20H17FO2S,C20H17FO2S Molecular Weight (g/mol): 340.41 MDL Number: MFCD00869764 InChI Key: LFWHFZJPXXOYNR-RQZCQDPDSA-N IUPAC Name: 2-[(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid SMILES: CSC1=CC=C(\C=C2/C(C)=C(CC(O)=O)C3=CC(F)=CC=C23)C=C1

Pricing and Availability
Specifications

CAS	32004-67-4
Molecular Weight (g/mol)	340.41
MDL Number	MFCD00869764
SMILES	CSC1=CC=C(\C=C2/C(C)=C(CC(O)=O)C3=CC(F)=CC=C23)C=C1
IUPAC Name	2-[(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
InChI Key	LFWHFZJPXXOYNR-RQZCQDPDSA-N
Molecular Formula	C20H17FO2S,C20H17FO2S

Thermo Scientific Chemicals Lck Inhibitor II

CAS: 918870-43-6 Molecular Formula: C24H26N6O3 Synonym: 3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)-pyrimidin-4-ylamino)-4-methylphenol;

Pricing and Availability
Specifications

CAS	918870-43-6
Synonym	3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)-pyrimidin-4-ylamino)-4-methylphenol;
Molecular Formula	C24H26N6O3

Thermo Scientific Chemicals Necrosis Inhibitor, IM-54

CAS: 861891-50-1 Molecular Formula: C19H23N3O2,C19H23N3O2 Molecular Weight (g/mol): 325.41 InChI Key: SGLOMINNEBLJFF-UHFFFAOYSA-N Synonym: 1-Methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione; IUPAC Name: 1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-2,5-dihydro-1H-pyrrole-2,5-dione SMILES: CCCCCNC1=C(C(=O)N(C)C1=O)C1=CN(C)C2=CC=CC=C12

Pricing and Availability
Specifications

CAS	861891-50-1
Molecular Weight (g/mol)	325.41
SMILES	CCCCCNC1=C(C(=O)N(C)C1=O)C1=CN(C)C2=CC=CC=C12
Synonym	1-Methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione;
IUPAC Name	1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-2,5-dihydro-1H-pyrrole-2,5-dione
InChI Key	SGLOMINNEBLJFF-UHFFFAOYSA-N
Molecular Formula	C19H23N3O2,C19H23N3O2

Thermo Scientific Chemicals IKK-2 Inhibitor V

CAS: 978-62-1 Molecular Formula: C15H8ClF6NO2,C15H8ClF6NO2 Molecular Weight (g/mol): 383.67 InChI Key: CHILCFMQWMQVAL-UHFFFAOYSA-N Synonym: N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide; IMD-0354 IUPAC Name: N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide SMILES: OC1=C(C=C(Cl)C=C1)C(=O)NC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F

Pricing and Availability
Specifications

CAS	978-62-1
Molecular Weight (g/mol)	383.67
SMILES	OC1=C(C=C(Cl)C=C1)C(=O)NC1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
Synonym	N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide; IMD-0354
IUPAC Name	N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
InChI Key	CHILCFMQWMQVAL-UHFFFAOYSA-N
Molecular Formula	C15H8ClF6NO2,C15H8ClF6NO2

Thermo Scientific Chemicals SANT-1

CAS: 304909-07-7 Molecular Formula: C23H27N5,C23H27N5 Molecular Weight (g/mol): 373.50 InChI Key: FOORCIAZMIWALX-UHFFFAOYSA-N Synonym: (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine IUPAC Name: N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine SMILES: CC1=NN(C(C)=C1C=NN1CCN(CC2=CC=CC=C2)CC1)C1=CC=CC=C1

Pricing and Availability
Specifications

CAS	304909-07-7
Molecular Weight (g/mol)	373.50
SMILES	CC1=NN(C(C)=C1C=NN1CCN(CC2=CC=CC=C2)CC1)C1=CC=CC=C1
Synonym	(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
IUPAC Name	N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
InChI Key	FOORCIAZMIWALX-UHFFFAOYSA-N
Molecular Formula	C23H27N5,C23H27N5

Thermo Scientific Chemicals N-Acetyl-D-sphingosine, 98%

CAS: 3102-57-6 Molecular Formula: C20H39NO3,C20H39NO3 Synonym: Acetyl ceramide; C2-Ceramide

Pricing and Availability
Specifications

CAS	3102-57-6
Synonym	Acetyl ceramide; C2-Ceramide
Molecular Formula	C20H39NO3,C20H39NO3

SB 202190, 99+%

CAS: 152121-30-7 Molecular Formula: C20H14FN3O,C20H14FN3O Synonym: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole

Pricing and Availability
Specifications

CAS	152121-30-7
Synonym	4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole
Molecular Formula	C20H14FN3O,C20H14FN3O

Thermo Scientific Chemicals SKF-96365 hydrochloride, 99+%

CAS: 130495-35-1 Molecular Formula: C22H27ClN2O3,C22H27ClN2O3 Synonym: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole

Pricing and Availability
Specifications

CAS	130495-35-1
Synonym	1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole
Molecular Formula	C22H27ClN2O3,C22H27ClN2O3

Signal Transduction Reagents and Kits

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