missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ NOTCH2 (Cleaved Ala1734) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA537433
Description
This antibody detects endogenous protein at a molecular weight of 85 and 110 kDa. Purity is >95% by SDS-PAGE.
The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions.Spécifications
| NOTCH2 (Cleaved Ala1734) | |
| Polyclonal | |
| Unconjugated | |
| NOTCH2 | |
| AGS2; AI853703; HJCYS; hN2; Motch B; N2; N2ECD; N2ICD; Neurogenic locus notch homolog protein 2; notch 2; Notch 2 extracellular truncation; Notch 2 intracellular domain; Notch gene homolog 2; Notch homolog 2; Notch2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 18129, 29492, 4853 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
| O35516, Q04721, Q9QW30 | |
| NOTCH2 | |
| Synthetic peptide corresponding to amino acids 1734-1800 of human Notch 2. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |