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Gibco™ Human Klotho Recombinant Protein, PeproTech® 
Recombinant Protein
$125.66 - $11551.52
Spécifications
| Accession Number | Q9UEF7 |
|---|---|
| For Use With (Application) | ELISA, Functional Assay, Western Blot |
| Formulation | protein with no preservative |
| Gene ID (Entrez) | 9365 |
| Name | Human Klotho |
| Numéro de catalogue | Numéro du manufacturier. | Quantity | Prix | Quantité | |||||
|---|---|---|---|---|---|---|---|---|---|
| Numéro de catalogue | Numéro du manufacturier. | Quantity | Prix | Quantité | |||||
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10053100UG
|
Gibco™
LS10053100UG |
100 μg |
chaque for $976.00
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100531MG
|
Gibco™
100531MG |
2 x 500 μg |
chaque for $4,630.00
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|
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10-053-01M
|
Gibco™
1005301M |
2 x 500 μg |
N/A
|
N/A | |||||
| Pour de laide SVP utiliser la function de clavardage; nous envoyer un couriel à help@thermofisher.com ou appelez le service à la clientèle au 1-800-234-7437. | |||||||||
|
1005320UG
|
Gibco™
1005320UG |
20 μg |
chaque for $302.74
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10053250UG
|
Gibco™
LS10053250UG |
250 μg |
chaque for $1,708.00
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10053500UG
|
Gibco™
10053500UG |
500 μg |
chaque for $2,794.12
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|
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100535UG
|
Gibco™
100535UG |
5 μg |
chaque for $125.66
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Description
100-53-1MG will be provided as 2 x 500 μg (100-53-500UG). Recombinant Human Klotho is a glycoprotein of 516 amino acid residues that migrates at an apparent molecular weight of 65-70 kDa by SDS-PAGE analysis under reducing conditions. Recombinant Human Klotho has a calculated molecular weight of 58.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.Specifications
| Q9UEF7 | |
| protein with no preservative | |
| Human Klotho | |
| RUO | |
| KL | |
| Recombinant | |
| Lyophilized |
| ELISA, Functional Assay, Western Blot | |
| 9365 | |
| CHO cells | |
| alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein | |
| Unconjugated | |
| EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |