Thermo Scientific™ CaptureSelect™ Biotin Anti-Gonadotropin Conjugate

Description

CaptureSelect Biotin Anti-Gonadotropin Conjugate consists of a 13 kDa recombinant single domain antibody fragment (V_HH affinity ligand) that specifically binds with high affinity and selectivity to the alpha chain of human gonadotropins. This group of human glycoprotein hormones includes human chorionic gonadotropin (HCG), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and follicle-stimulating hormone (FSH), which all possess an identical alpha chain subunit.

The affinity ligand is chemically conjugated to biotin via an appropriate spacer that retains the binding reactivity of the ligand when used in combination with streptavidin-based conjugates or streptavidin pre-coated surfaces. This conjugate allows you to detect, quantitate, and characterize native and recombinant human gonadotropins.

Applications for CaptureSelect Biotin Anti-Gonadotropin Conjugate include ELISA, immunoprecipitation with streptavidin-coupled DynaBeads, Gyrolab™-based immunoassays, and label-free detection using platforms such as those based on surface plasmon resonance (Biacore™ and IBIS-MX96 systems) and bio-layer interferometry (ForteBio™ Octet™ systems).

Animal origin statement

CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (V_HH) created by a proprietary technology. The V_HH affinity ligand is a 12–15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).