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AF6 Polyclonal Antibody, Bethyl Laboratories 
Rabbit Polyclonal Antibody
$344.88 - $344.88
Specifications
| Antigen | AF6 |
|---|---|
| Applications | Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Form | Liquid |
Description
The recommended shelf life for this product is 1 year from date of receipt.
AF-6, also known as afadin, is expressed in a variety of cell types. At least 5 isoforms of this protein are produced by alternative splicing and the 'canonical' sequence is designated as l-afadin. Chromosomal aberration of the MLLT4 gene and tight junctions and Notch signaling pathways cross-communication. This happens through physical interaction with Ras, Notch and Dishevelled, a key Wingless effector. AF-6 also controls integrin-mediated cell adhesion. This is done at least partially by regulating Rap1 activation through recruitment of both SPA-1 and Rap1GTP. These results demonstrate that AF-6 is an important molecule mediating cell-cell adhesion but is also capable of modulating several key signaling pathways.Specifications
| AF6 | |
| Polyclonal | |
| Liquid | |
| RUO | |
| TBS with 0.1% BSA and 0.09% sodium azide | |
| AF6, AF-6, ALL1-fused gene from chromosome 6 protein, MLL-AF6, myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 4, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4, protein AF-6 | |
| AFDN | |
| IgG | |
| Antigen affinity chromatography | |
| Antibody |
| Western Blot | |
| Unconjugated | |
| Rabbit | |
| Human | |
| P55196 | |
| 4301 | |
| Between 1475 and 1525 | |
| Primary | |
| 4° C | |
| AFDN |