Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
Silencer™ Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry.
Silencer™ Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry.
The Silencer™ Select Human Drug Targets siRNA Library contains 23,778 Ambion™ Silencer Select highly potent and chemically-modified siRNAs targeting 7,926 genes for performing RNAi screens against known human drug target genes.
The Silencer™ Human Apoptosis siRNA Library provides investigators with a focused siRNA screening platform targeting apoptosis genes and enabling a detailed analysis of the apoptotic signaling pathway.
The Silencer™ Human Cancer Genome siRNA Library contains 1572 Ambion™ Silencer siRNAs targeting 524 gene targets that are commonly affected in cancers.
The Silencer™ Select Human Membrane Trafficking siRNA Library is designed for researchers targeting proteins known or predicted to participate in membrane trafficking or remodeling.
Ion channels are key components in a multitude of biological processes, including rapid changes in muscle cell contractions, epithelial transport of nutrients and ions, T cell activation and pancreatic beta-cell insulin release.
The Silencer™ Select Human Epigenetics siRNA Library contains 1563 Ambion™ Silencer Select highly potent, chemically-modified siRNAs targeting 521 epigenetic enzymes, including those mediating epigenetic signaling through the acetylation and methylation of histones.
The Silencer™ Select Human Apoptosis siRNA Library provides investigators with a focused siRNA screening platform targeting apoptosis genes and enabling a detailed analysis of the apoptotic signaling pathway.