Ambion™ Silencer™ Validated siRNA

• The Silencer™ Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry
• Silencer™ Select Validated siRNAs are functionally tested to reduce target gene expression
• Sets of Silencer™ Select siRNA Libraries are also available in tubes or plate for high throughput screening
• The Silencer™ Select Positive and Negative Control RNAs should be included in every siRNA experiment

The benefits of using Silencer™ Select siRNAs include:

• Potent – up to 100-fold more potent than currently available siRNAs and fewer off-target effects
• Most Specific – LNA™ chemical modifications reduce off-target effects by up to 90%
• Reliable – demonstrated improvements in consistency and reliability of phenotypic results
• Guaranteed – 100% guaranteed to silence, the best guarantee in the industry

Note: Silencer™ Pre-Designed & Validated siRNAs are designed using our first-generation algorithm and DO NOT include any chemical modifications. They are recommended for completing in vitro RNAi studies that were started using Silencer™ siRNAs. For new studies we recommend Silencer Select siRNAs.

Approximate Turnaround Times*

• Standard purification: 4 business days
• HPLC purification: 6 business days (20 and 40 nmol); 15 business days (250 nmol)
• In Vivo Ready: 15 business days (250 nmol)