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  6. Thermo Scientific Chemicals U0126, 99+%

Thermo Scientific Chemicals U0126, 99+%

Catalog No. AAJ61246MC
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Catalog No. AAJ61246MC Supplier Thermo Scientific Chemicals Supplier No. J61246MC
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Description

Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2 | CAS: 109511-58-2 | C18H16N6S2, C18H16N6S2 | 380.49 g/mol

U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

CAS 109511-58-2
Molecular Formula C18H16N6S2
Synonym 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene

Specifications

Quantity 100 mg
Description White
Content And Storage -30°C to -10°C
For Use With (Application) Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2
Formula Weight 380.49g/mol
Solubility Soluble in DMSO; Poorly soluble in ethanol and water
Product Type Signal Transduction Reagent
Form Powder
InChI Key DVEXZJFMOKTQEZ-JYFOCSDGSA-N
SMILES N\C(SC1=CC=CC=C1N)=C(\C#N)/C(/C#N)=C(\N)SC1=CC=CC=C1N
IUPAC Name (2Z,3Z)-bis({amino[(2-aminophenyl)sulfanyl]methylidene})butanedinitrile
Molecular Weight (g/mol) 380.49
Assay ≥99%
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Safety and Handling

Recommended Storage Store at -20°C

RUO – Research Use Only