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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1

Thermo Scientific™ DTBP (Wang and Richard's Reagent)

Crosslink amines to amines with dithiobispropionimidate; composed of imidoester groups at either end of a reducible (cleavable) disulfide-containing spacer arm.

2

Thermo Scientific™ Pierce™ Controlled Protein-Protein Crosslinking Kit

Chemically conjugate any two purified proteins (antibodies, enzymes, carriers, etc.) using sulfo-SMCC crosslinker, a complete kit with modification reagents and buffers.

3

Thermo Scientific™ Mass Spectrometry Compatible Crosslinkers

Improve mass spectrometry detection of crosslinked proteins and interactions with DSPP and TBDSPP heterotrifunctional crosslinkers.

Content And Storage Upon receipt store at -20°C protected from moisture.
Format Standard
Cleavable No
Product Type Crosslinker
Form Solid
Reactive Moiety NHS Ester
Spacer Arm Length 4.3 Å
Quantity 50 mg
Labeling Method Chemical Labeling
Crosslinker Type Homotrifunctional
Chemical Reactivity Amine-Amine
Product Line MS Reagents
PEGylated No
4

Thermo Scientific™ DMP (dimethyl pimelimidate)

Crosslink amines to amines with dimethyl pimelimidate (CAS 58537-94-3); composed of imidoester groups and a membrane-permeable, 7-atom spacer arm.

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Description DMP
Cleavable No
Water Soluble Yes
Form Powder
Molecular Weight (g/mol) 259.17
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Imidoester
Spacer Arm Length 9.2 Å
Product Line Pierce
PEGylated No
5

Thermo Scientific™ DSS (disuccinimidyl suberate), No-Weigh™ Format

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Cleavable No
PEGylated No
6

Thermo Scientific™ Pierce™ Premium Grade EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride)

Optimize applications where product integrity and risk minimization are paramount with this high-quality formulation of carbodiimide crosslinker.

Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 191.7
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Carboxyl
Cell Permeability No
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Short (<10 Å)
Reactive Moiety Carbodiimide
Spacer Arm Length 0.0 Å
Product Line Pierce
PEGylated No
7

Thermo Scientific™ Pierce™ Premium Grade DSP (dithiobis(succinimidyl propionate))

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this popular amine-reactive, cleavable crosslinker.

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at 4°C.
Cleavable By Thiols
Water Soluble No
Form Powder
Molecular Weight (g/mol) 404.42
Solubility DMF, DMSO
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability Yes
Format Standard, Single-use, Premium-grade
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Formulation Dithiobis(succinimidylpropionate); powder solid
Reactive Moiety NHS Ester
Spacer Arm Length 12.0 Å
Product Line Pierce
PEGylated No
8

Thermo Scientific™ PMPI (p-maleimidophenyl isocyanate)

Short (8.7A) hydroxyl-to-sulfhydryl crosslinker; isocyanate and maleimide groups; label -OH by urethane bonds for conjugation to cysteines by thioether bonds.

9

Thermo Scientific™ SM(PEG)12 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Cleavable No
Water Soluble Yes
Form Liquid
Molecular Weight (g/mol) 865.92
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Long (>30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 53.4 Å
Product Line Pierce
PEGylated Yes
10

Thermo Scientific™ Sulfo-NHS (N-hydroxysulfosuccinimide), No-Weigh™ Format

Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Molecular Weight (g/mol) 217.13
Solubility Water
PEGylated No
11

Thermo Scientific™ DST (disuccinimidyl tartrate)

Crosslink amines to amines with disuccinimidyl tartrate, composed of NHS-ester groups and a diol-containing spacer arm (6.4A) that is periodate-cleavable.

12

Thermo Scientific™ Sulfo-KMUS (N-κ-maleimidoundecanoyl-oxysulfosuccinimide ester)

Crosslink amines to sulfhydryls with this long crosslinker composed of sulfo-NHS-ester and maleimide groups at ends of an aliphatic, 13-atom (16.3A) spacer arm.

13

Thermo Scientific™ BS3-d4 (bis(sulfosuccinimidyl) 2,2,7,7-suberate-d4)

Crosslink amines to amines using these heavy (deuterated) and light matched pairs of an 11.4A, NHS-ester crosslinker for mass spectrometry analysis of protein interactions.

14

Thermo Scientific™ Sulfo-EGS (ethylene glycol bis(sulfosuccinimidyl succinate))

Crosslink amines to amines with a crosslinker composed of sulfo-NHS-ester groups and hydroxylamine-cleavable spacer arm; water-soluble for cell-surface protein crosslinking.

15

Thermo Scientific™ SM(PEG)24 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).