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Thermo Scientific™ PMPI (p-maleimidophenyl isocyanate)

Catalog No. PI28100
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50 mg
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Catalog No. Quantity
PI28100 50 mg
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Catalog No. PI28100 Supplier Thermo Scientific™ Supplier No. LSG28100
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Description

Short (8.7A) hydroxyl-to-sulfhydryl crosslinker; isocyanate and maleimide groups; label -OH by urethane bonds for conjugation to cysteines by thioether bonds.

Thermo Scientific™ Pierce PMPI is a maleimide-and-isocyanate crosslinker for attaching compounds to sulfhydryl groups (cysteines) after conjugating the linker to hydroxyl groups on a molecule by urethane (carbamate) bonds.

Highlights:

  • Maleimide forms stable thioether linkages
  • Isocyanate reacts with - OH groups to form a carbamate link at pH 8.5
  • Excellent tool for conjugating - OH group-containing compounds such as steroids and vitamins
  • Reactive groups: maleimide and isocyanate
  • Reactive toward: sulfhydryl and hydroxyl groups

Specifications

Chemical Reactivity Carboxyl-Sulfhydryl
Cleavable No
Description PMPI
Molecular Weight (g/mol) 307.1
PEGylated No
Spacer Arm Length 8.7 Å
Content And Storage Upon receipt store at 4°C protected from moisture.
Cell Permeability Not determined
Shipping Condition Ambient
Product Line Pierce
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Maleimide, Isocyanate
Spacer Short (<10 Å)
Form Solid
Quantity 50 mg
Solubility DMF, DMSO
Format Standard
Water Soluble No
Product Type Crosslinker
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For Research Use Only. Not for use in diagnostic procedures.