Search results for "Selleck Chemical LLC"
Selleck Chemicals Co Ltd Y-27632 2HCl 10mg 129830-38-2
Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd SLLCK CHEM LLC PIRFENIDON 50MG
361057581 SLLCK CHEM LLC PIRFENIDON 50MG
Selleck Chemicals Co Ltd Rucaparib (AG-014699) phosphate 10mg 459868-92-9 PF-01367338
Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd U0126-EtOH 25mg 1173097-76-1
U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 ?M/0.06 ?M in cell-free assays, 100-fold higher affinity for ?N3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd Ruxolitinib (INCB018424) 5mg 941678-49-5
Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd PHA-793887 5mg 718630-59-2
PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM. It is greater than 6-fold more selective for CDK2, 5, and 7 than CDK1, 4, and 9. PHA-793887 induces cell-cycle arrest and apoptosis. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd Panobinostat (LBH589) 200mg 404950-80-7 NVP-LBH589
Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd Y-27632 2HCl 50mg 129830-38-2
Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd LY294002 10mg 154447-36-6 SF 1101, NSC 697286
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3K?/?/? with IC50 of 0.5 ?M/0.57 ?M/0.97 ?M, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd Palbociclib (PD-0332991) HCl 10mg 827022-32-2
Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd Palbociclib (PD-0332991) HCl 50mg 827022-32-2
Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd TWS119 10mg 601514-19-6
TWS119 is a GSK-3? inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3? inhibition triggers autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd Idelalisib (CAL-101, GS-1101) 10mg 870281-82-6
Idelalisib (CAL-101, GS-1101) is a selective p110? inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110? than p110?/?/?, and 400- to 4000-fold more selectivity to p110? than C2?, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd Panobinostat (LBH589) 10mg 404950-80-7 NVP-LBH589
Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemicals Co Ltd Olaparib (AZD2281) 100mg 763113-22-0 Ku-0059436
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations. *For Research & Development use only. Product is not intended for drug, household, or human consumption.