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Thermo Scientific™ Pierce™ Iodination Beads

Easily and gently label (iodinate) proteins and peptides with iodine-125 using reagent-coated polystyrene beads that can be removed following reaction.

Manufacturer: thermo scientific™  PI28665

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Catalog No. PI28665


Description & Specifications


Description Pierce Iodination Beads
Formulation Polystyrene beads (3mm dia.) coated with iodination reagent
Quantity 50 beads
Sufficient For 10 to 50 reactions, each with 0.1 to 0.5 mg of protein

Thermo Scientific™ Pierce Iodination Beads are 3mm diameter polystyrene beads that are coated with an oxidizing reagent, which provides efficient activation of iodine-125 for protein or peptide iodination procedures.


  • Derivatized, uniform, nonporous polystyrene beads
  • Radioiodide incorporation as high as 99%; labeled protein recovery >90%
  • Functions over a broad pH and temperature range
  • Fast and easy to use: iodinations complete in 2 to 15 minutes
  • Reaction stopped by simply removing beads from reaction mixture with tweezers or pasteur pipet; no reducing agent necessary to terminate reaction

Additional Features:

  • Iodinates in the presence of azides, detergents, urea and high salt
  • Allows efficient iodination of cell membrane surface proteins
  • More gentle method for iodination than soluble chloramine-T because there is no contact between the protein and the immobilized oxidizing agent1
  • Highly reproducible iodinations
  • Can be used to quantitatively iodinate histidine at pH 8.22