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Thermo Scientific™ Pierce™ Sodium meta-Periodate

Catalog No. PI20504
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25 g
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Catalog No. Quantity
PI20504 25 g
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Catalog No. PI20504 Supplier Thermo Scientific™ Supplier No. 20504
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Description

Gently oxidize glycoprotein carbohydrate sugars to create reactive aldehydes (carbonyls) for crosslinking and immobilization using NaIO4 (CAS 7790-28-5).

Thermo Scientific™ Pierce Sodium meta-Periodate is a gentle oxidizing agent that effectively cleaves cis-diols in carbohydrate sugars to create reactive aldehydes, providing many uses relating to the study and detection of glycoproteins.

Highlights:

  • Capable of the oxidation of cis-diols to aldehydes
  • ACS reagent grade
  • White, crystalline, free-flowing

Specifications

Content And Storage Upon receipt store at room temperature.
Label or Dye Aldehyde Group
Label Type Conjugating Groups
Product Line Pierce
Form Powder
Quantity 25 g
Product Type Sodium Meta-Periodate

Frequently Asked Questions (FAQs)

What would be the best way to crosslink an antibody with horseradish peroxidase (‘HRP’ unmodified)?

A commonly used method for conjugating HRP to antibodies is by activation of the HRP using sodium meta-periodate (Cat no. 20504) to generate aldehydes. After the reaction, the HRP must be dialyzed to remove the meta-periodate; then the aldehydes on the HRP will react directly to the amine groups on the antibody. Alternatively, we offer activated HRP (Cat. No. 31488) as an alternative to avoid the periodate oxidation step to modify the HRP. 

For Research Use Only. Not for use in diagnostic procedures.